Human α-Defensin 6 Promotes Mucosal Innate Immunity Through Self-Assembled Peptide Nanonets

Article Properties
  • Language
    English
  • Publication Date
    2012/07/27
  • Journal
  • Indian UGC (journal)
  • Refrences
    31
  • Citations
    284
  • Hiutung Chu Department of Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95616, USA.
  • Marzena Pazgier Institute of Human Virology and Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
  • Grace Jung Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
  • Sean-Paul Nuccio Department of Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95616, USA.
  • Patricia A. Castillo Department of Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95616, USA.
  • Maarten F. de Jong Department of Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95616, USA.
  • Maria G. Winter Department of Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95616, USA.
  • Sebastian E. Winter Department of Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95616, USA.
  • Jan Wehkamp Department of Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95616, USA.
  • Bo Shen Department of Gastroenterology and Hepatology, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
  • Nita H. Salzman Department of Pediatrics, Division of Gastroenterology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
  • Mark A. Underwood Department of Pediatrics, School of Medicine, University of California, Davis, CA 95616, USA.
  • Renee M. Tsolis Department of Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95616, USA.
  • Glenn M. Young Department of Food Science and Technology, University of California, Davis, CA 95616, USA.
  • Wuyuan Lu Institute of Human Virology and Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
  • Robert I. Lehrer Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
  • Andreas J. Bäumler Department of Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95616, USA.
  • Charles L. Bevins Department of Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95616, USA.
Abstract
Cite
Chu, Hiutung, et al. “Human α-Defensin 6 Promotes Mucosal Innate Immunity Through Self-Assembled Peptide Nanonets”. Science, vol. 337, no. 6093, 2012, pp. 477-81, https://doi.org/10.1126/science.1218831.
Chu, H., Pazgier, M., Jung, G., Nuccio, S.-P., Castillo, P. A., de Jong, M. F., Winter, M. G., Winter, S. E., Wehkamp, J., Shen, B., Salzman, N. H., Underwood, M. A., Tsolis, R. M., Young, G. M., Lu, W., Lehrer, R. I., Bäumler, A. J., & Bevins, C. L. (2012). Human α-Defensin 6 Promotes Mucosal Innate Immunity Through Self-Assembled Peptide Nanonets. Science, 337(6093), 477-481. https://doi.org/10.1126/science.1218831
Chu, Hiutung, Marzena Pazgier, Grace Jung, Sean-Paul Nuccio, Patricia A. Castillo, Maarten F. de Jong, Maria G. Winter, et al. “Human α-Defensin 6 Promotes Mucosal Innate Immunity Through Self-Assembled Peptide Nanonets”. Science 337, no. 6093 (2012): 477-81. https://doi.org/10.1126/science.1218831.
Chu H, Pazgier M, Jung G, Nuccio SP, Castillo PA, de Jong MF, et al. Human α-Defensin 6 Promotes Mucosal Innate Immunity Through Self-Assembled Peptide Nanonets. Science. 2012;337(6093):477-81.
Refrences
Title Journal Journal Categories Citations Publication Date
10.1016/B978-012491543-5/50010-3
10.1128/AAC.49.1.269-275.2005
Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin Nature
  • Science: Science (General)
522 2003
Broad-spectrum antimicrobial activity of human intestinal defensin 5

Infection and Immunity
  • Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
  • Medicine: Internal medicine: Infectious and parasitic diseases
46 1997
Paneth's disease

Journal of Crohn's and Colitis
  • Medicine: Internal medicine: Specialties of internal medicine: Diseases of the digestive system. Gastroenterology
  • Medicine: Internal medicine: Specialties of internal medicine: Diseases of the digestive system. Gastroenterology
  • Medicine: Medicine (General)
85 2010
Citations
Title Journal Journal Categories Citations Publication Date
Understanding the Dynamics of Human Defensin Antimicrobial Peptides: Pathogen Resistance and Commensal Induction Applied Biochemistry and Biotechnology
  • Science: Biology (General)
  • Technology: Chemical technology: Biotechnology
  • Science: Biology (General)
  • Science: Chemistry: Organic chemistry: Biochemistry
  • Science: Biology (General)
  • Science: Chemistry: Organic chemistry: Biochemistry
2024
Balancing Act of the Intestinal Antimicrobial Proteins on Gut Microbiota and Health

Journal of Microbiology
  • Science: Microbiology
2024
Combating bacterial infections with host defense peptides: Shifting focus from bacteria to host immunity Drug Resistance Updates
  • Medicine: Public aspects of medicine: Toxicology. Poisons
  • Medicine: Therapeutics. Pharmacology
1 2024
In situ captured antibacterial action of membrane-incising peptide lamellae

Nature Communications
  • Science
  • Science: Science (General)
2024
A self-assembling peptide inhibits the growth and function of fungi via a wrapping strategy

Biomaterials Science
  • Technology: Chemical technology: Biotechnology
  • Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
2024
Citations Analysis
Category Category Repetition
Science: Biology (General)73
Science: Chemistry: Organic chemistry: Biochemistry49
Medicine: Medicine (General)45
Science: Chemistry39
Science: Microbiology38
Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy38
Medicine: Internal medicine: Specialties of internal medicine: Diseases of the digestive system. Gastroenterology27
Science: Chemistry: General. Including alchemy26
Medicine: Therapeutics. Pharmacology24
Medicine23
Science: Science (General)22
Medicine: Public aspects of medicine: Toxicology. Poisons20
Science: Biology (General): Cytology19
Science: Biology (General): Genetics17
Science17
Technology: Chemical technology: Biotechnology15
Science: Physics15
Science: Chemistry: Physical and theoretical chemistry13
Science: Chemistry: Analytical chemistry12
Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials12
Medicine: Internal medicine: Infectious and parasitic diseases12
Technology: Chemical technology11
Medicine: Medicine (General): Medical technology7
Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens5
Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry4
Agriculture: Animal culture: Veterinary medicine3
Agriculture: Plant culture3
Agriculture: Animal culture3
Medicine: Internal medicine3
Medicine: Surgery3
Technology: Chemical technology: Polymers and polymer manufacture3
Medicine: Internal medicine: Specialties of internal medicine: Diseases of the genitourinary system. Urology3
Medicine: Pathology3
Medicine: Gynecology and obstetrics2
Science: Biology (General): Reproduction2
Science: Physics: Atomic physics. Constitution and properties of matter2
Science: Chemistry: Organic chemistry2
Medicine: Dermatology2
Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system2
Science: Mathematics: Instruments and machines: Electronic computers. Computer science2
Technology: Chemical technology: Food processing and manufacture2
Medicine: Pharmacy and materia medica2
Science: Physiology2
Medicine: Other systems of medicine2
Science: Chemistry: Inorganic chemistry1
Science: Physics: Nuclear and particle physics. Atomic energy. Radioactivity1
Technology: Engineering (General). Civil engineering (General): Environmental engineering1
Technology: Chemical technology: Chemical engineering1
Technology: Engineering (General). Civil engineering (General)1
Agriculture: Aquaculture. Fisheries. Angling1
Science: Zoology1
Science: Botany1
Medicine: Internal medicine: Special situations and conditions: Geriatrics1
Technology: Home economics: Nutrition. Foods and food supply1
Agriculture1
Agriculture: Agriculture (General)1
Medicine: Internal medicine: Specialties of internal medicine: Diseases of the endocrine glands. Clinical endocrinology1
Medicine: Medicine (General): Computer applications to medicine. Medical informatics1
Science: Physics: Optics. Light1
Geography. Anthropology. Recreation: Environmental sciences1
Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine1
Medicine: Internal medicine: Specialties of internal medicine: Diseases of the blood and blood-forming organs1
Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system1
The category Science: Biology (General) 73 is the most commonly referenced area in studies that cite this article. The first research to cite this article was titled Kits for RNA Extraction, Isolation, and Purification and was published in 2012. The most recent citation comes from a 2024 study titled In situ captured antibacterial action of membrane-incising peptide lamellae. This article reached its peak citation in 2022, with 29 citations. It has been cited in 183 different journals, 25% of which are open access. Among related journals, the Frontiers in Immunology cited this research the most, with 8 citations. The chart below illustrates the annual citation trends for this article.
Citations used this article by year