JCI Insight

Title Publication Date Language Citations
Inhibition of cysteine protease cathepsin Lincreases the level and activity of lysosomal glucocerebrosidase2024/02/08English
Sema6D forward signaling impairs T cell activation and proliferation in head and neck cancer2024/02/08English
Cold stress–induced ferroptosis in liver sinusoidal endothelial cells determines liver transplant injury and outcomes2024/02/08English
Intergenic sequences harboring potential enhancer elements contribute to Axenfeld-Rieger syndrome by regulating PITX22024/04/09English
Allelic heterogeneity of TTNtv dilated cardiomyopathy can be modeled in adult zebrafish2024/04/08English
Molecular subtyping improves breast cancer diagnosis in the Copenhagen Breast Cancer Genomics Study2024/04/08English
Adverse outcomes and an immunosuppressed endotype in septic patients with reduced IFN-γ ELISpot2024/01/23English
The super-healing MRL strain promotes muscle growth in muscular dystrophy through a regenerative extracellular matrix2024/01/04English
Immunoglobulin replacement products confer in vivo protection against SARS-CoV-2 XBB.1.5 Omicron variant despite poor neutralizing activity2024/01/04English
Unbalancing cAMP and Ras/MAPK pathways as a therapeutic strategy for cutaneous neurofibromas2024/01/04English
Sarm1 knockout prevents type 1 diabetic bone disease in females independent of neuropathy2024/01/04English
IRF5 governs macrophage adventitial infiltration to fuel abdominal aortic aneurysm formation2024/01/04English
hsa-miRNA-548v controls the viscoelastic properties of human cardiomyocytes and improves their relaxation rates2024/01/02English
CRISPR screening identifies BET and mTOR inhibitor synergy in cholangiocarcinoma through serine glycine one carbon2024/01/23English
New polyclonal antibodies, inhibit selectively tumor growth and invasion and synergize with immune checkpoint inhibitors2023/12/12English
Macrophage RAGE activation is proinflammatory in NASH2024/01/04English
Evolutionary mode and timing of dissemination of high-grade serous carcinomas2024/01/04English
Toxin-neutralizing Abs are associated with improved T cell function following recovery from Staphylococcus aureus infection2024/01/18English
HNF1α maintains pancreatic α and β cell functions in primary human islets2023/12/22English
FGF23 directly inhibits osteoprogenitor differentiation in Dmp1-knockout mice2023/12/22English
Human hepatic organoids for the analysis of human genetic diseases2023/10/23English
SET7/9-mediated methylation affects oncogenic functions of histone demethylase JMJD2A2023/10/23English
Human HLA-DR+CD27+ regulatory T cells show enhanced antigen-specific suppressive function2023/12/08English
RhoA vesicle trafficking–mediated transglutaminase 2 membrane translocation promotes IgA1 mesangial deposition in IgA nephropathy2023/10/09English
Platelet factor 4 limits neutrophil extracellular trap– and cell-free DNA–induced thrombogenicity and endothelial injury2023/11/22English
Region-specific Wnt signaling responses promote gastric polyp formation in patients with familial adenomatous polyposis2023/11/09English
Validation of a murine proteome-wide phage display library for identification of autoantibody specificities2023/12/08English
SLC25A21 downregulation promotes KRAS-mutant colorectal cancer progression by increasing glutamine anaplerosis2023/11/08English
Remote effects of kidney drug transporter OAT1 on gut microbiome composition and urate homeostasis2023/11/08English
Dabrafenib protects from cisplatin-induced hearing loss in a clinically relevant mouse model2023/12/22English