JCI Insight

Title Publication Date Language Citations
Cholestanol accelerates α-synuclein aggregation and spreading by activating asparagine endopeptidase2023/11/08English
Pericentrin deficiency in smooth muscle cells augments atherosclerosis through HSF1-driven cholesterol biosynthesis and PERK activation2023/11/08English
HIPK2 C-terminal domain inhibits NF-κB signaling and renal inflammation in kidney injury2024/03/21English
Mapping SCA1 regional vulnerabilities reveals neural and skeletal muscle contributions to disease2024/03/21English
Activation of the IKK2/NF-κB pathway in VSMCs inhibits calcified vascular stiffness in CKD2024/04/08English
A T cell–based SARS-CoV-2 spike protein vaccine provides protection without antibodies2024/01/23English
Tumor treating fields suppress tumor cell growth and neurologic decline in models of spine metastases2024/03/21English
Macrophage-enriched Sectm1a promotes efficient efferocytosis to attenuate ischemia/reperfusion-induced cardiac injury2024/03/08English
Prolonged exposure to lung-derived cytokines is associated with activation of microglia in patients with COVID-192024/03/19English
Dysregulated fibrinolysis and plasmin activation promote the pathogenesis of osteoarthritis2024/03/19English
Tubular CPT1A deletion minimally affects aging and chronic kidney injury2024/02/22English
Intragraft memory-like CD127hiCD4+Foxp3+ Tregs maintain transplant tolerance2024/02/13English
Modeling skeletal dysplasia in Hurler syndrome using patient-derived bone marrow osteoprogenitor cells2024/03/08English
HSPA12A maintains aerobic glycolytic homeostasis and Histone3 lactylation in cardiomyocytes to attenuate myocardial ischemia/reperfusion injury2024/04/08English
Natural antibodies drive type 2 immunity in response to damage associated molecular patterns2024/03/12English
Neutrophil proteases are protective against SARS-CoV-2 by degrading the spike protein and dampening virus-mediated inflammation2024/04/08English
OGDH and Bcl-xL loss causes synthetic lethality in glioblastoma2024/03/14English
Stimulation of skeletal stem cells in the growth plate promotes linear bone growth2024/02/13English
GNTI-122: an autologous antigen-specific engineered Treg cell therapy for type 1 diabetes2024/02/08English
Increasing Sufu gene dosage reveals its unorthodoxical role in promoting polydactyly and medulloblastoma tumorigenesis2024/02/15English
Single-cell analyses of metastatic bone marrow in human neuroblastoma reveals microenvironmental remodeling and metastatic signature2024/02/15English
Combining antibiotic with anti-TLR2/TLR13 therapy prevents brain pathology in pneumococcal meningitis2024/02/15English
Potently neutralizing human mAbs against the zoonotic pararubulavirus Sosuga virus2023/04/24English
Establishment of a reproducible and minimally invasive ischemic stroke model in swine2023/04/24English
Upregulation of acid ceramidase contributes to tumor progression in tuberous sclerosis complex2023/05/08English
Catalytic isoforms of AMP-activated protein kinase differentially regulate IMPDH activity and photoreceptor neuron function2024/01/16English
Myeloid Zfhx3 deficiency protects against hypercapnia-induced suppression of host defense against influenza A virus2024/01/16English
Purine nucleoside phosphorylase inhibition- an effective approach for the treatment of chemical hemorrhagic cystitis2024/01/25English
Norepinephrine induces anoikis resistance in high-grade serous ovarian cancer precursor cells2024/01/25English
Lipodystrophy in methylmalonic acidemia associated with elevated FGF21 and abnormal methylmalonylation2024/02/22English