Systems biology‐embedded target validation: improving efficacy in drug discovery

Article Properties
  • Language
    English
  • DOI (url)
    10.1002/wsbm.1253
  • Publication Date
    2013/11/08
  • Journal
    WIREs Systems Biology and Medicine
  • Indian UGC (journal)
  • Refrences
    70
  • Citations
    14
  • Drieke Vandamme Systems Biology Ireland University College Dublin Dublin Ireland
  • Benedikt A. Minke Systems Biology Ireland University College Dublin Dublin Ireland
  • William Fitzmaurice Systems Biology Ireland University College Dublin Dublin Ireland
  • Boris N. Kholodenko Systems Biology Ireland University College Dublin Dublin IrelandConway Institute of Biomolecular & Biomedical Research University College Dublin Dublin IrelandSchool of Medicine and Medical Science University College Dublin Dublin Ireland
  • Walter Kolch Systems Biology Ireland University College Dublin Dublin IrelandConway Institute of Biomolecular & Biomedical Research University College Dublin Dublin IrelandSchool of Medicine and Medical Science University College Dublin Dublin Ireland
Abstract
Cite
Vandamme, Drieke, et al. “Systems biology‐embedded Target Validation: Improving Efficacy in Drug Discovery”. WIREs Systems Biology and Medicine, vol. 6, no. 1, 2013, pp. 1-11, https://doi.org/10.1002/wsbm.1253.
Vandamme, D., Minke, B. A., Fitzmaurice, W., Kholodenko, B. N., & Kolch, W. (2013). Systems biology‐embedded target validation: improving efficacy in drug discovery. WIREs Systems Biology and Medicine, 6(1), 1-11. https://doi.org/10.1002/wsbm.1253
Vandamme D, Minke BA, Fitzmaurice W, Kholodenko BN, Kolch W. Systems biology‐embedded target validation: improving efficacy in drug discovery. WIREs Systems Biology and Medicine. 2013;6(1):1-11.
Refrences
Title Journal Journal Categories Citations Publication Date
Thalidomide and analogues: potential for immunomodulation of inflammatory and neoplastic dermatologic disorders 2010
Network based analysis of genome wide association data provides novel candidate genes for lipid and lipoprotein traits
Aspirin Inhibits Colon Cancer Cell and Tumor Growth and Downregulates Specificity Protein (Sp) Transcription Factors PLOS ONE
  • Medicine
  • Science
  • Science: Science (General)
 97 2012
The future of drug development: advancing clinical trial design Nature Reviews Drug Discovery
  • Technology: Chemical technology: Biotechnology
  • Medicine: Therapeutics. Pharmacology
  • Medicine: Public aspects of medicine: Toxicology. Poisons
 92 2009
Phase III and submission failures: 2007–2010 Nature Reviews Drug Discovery
  • Technology: Chemical technology: Biotechnology
  • Medicine: Therapeutics. Pharmacology
  • Medicine: Public aspects of medicine: Toxicology. Poisons
 303 2011
Citations
Title Journal Journal Categories Citations Publication Date
Identification of candidate target genes of oral squamous cell carcinoma using high-throughput RNA-Seq data and in silico studies of their interaction with naturally occurring bioactive compounds Journal of Biomolecular Structure and Dynamics
  • Science: Biology (General)
  • Science: Biology (General)
  • Science: Physics
  • Science: Biology (General)
  • Science: Chemistry: Organic chemistry: Biochemistry
  • Science: Biology (General)
  • Science: Chemistry: Organic chemistry: Biochemistry
 2023
Contemporary challenges in the European pharmaceutical industry: a systematic literature review

 Measuring Business Excellence
  • Social Sciences: Commerce: Business
 2022
A multicomponent screen for feeding behaviour and nutritional status in Drosophila to interrogate mammalian appetite-related genes Molecular Metabolism
  • Medicine: Internal medicine: Specialties of internal medicine: Diseases of the endocrine glands. Clinical endocrinology
  • Science: Biology (General)
  • Science: Chemistry: Organic chemistry: Biochemistry
 1 2021
Bioinformatics Accelerates the Major Tetrad: A Real Boost for the Pharmaceutical Industry

 International Journal of Molecular Sciences
  • Science: Biology (General)
  • Science: Chemistry: General. Including alchemy
  • Science: Chemistry
 15 2021
Facilitating Antiviral Drug Discovery Using Genetic and Evolutionary Knowledge

 Viruses
  • Science: Microbiology
  • Science: Microbiology
  • Science: Microbiology
 4 2021
Citations Analysis
Category Category Repetition
Science: Biology (General)7
Science: Chemistry: Organic chemistry: Biochemistry6
Technology: Chemical technology: Biotechnology3
Medicine: Therapeutics. Pharmacology3
Medicine: Public aspects of medicine: Toxicology. Poisons3
Science: Biology (General): Genetics2
Medicine: Medicine (General): Computer applications to medicine. Medical informatics2
Social Sciences: Commerce: Business1
Science: Physiology1
Science: Physics1
Medicine: Internal medicine: Specialties of internal medicine: Diseases of the endocrine glands. Clinical endocrinology1
Science: Mathematics: Instruments and machines: Electronic computers. Computer science1
Science: Chemistry: General. Including alchemy1
Science: Chemistry1
Science: Microbiology1
Science: Biology (General): Cytology1
The category Science: Biology (General) 7 is the most commonly referenced area in studies that cite this article. The first research to cite this article was titled Drug discovery and the maze of biological complexity: an editorial essay and was published in 2014. The most recent citation comes from a 2023 study titled Identification of candidate target genes of oral squamous cell carcinoma using high-throughput RNA-Seq data and in silico studies of their interaction with naturally occurring bioactive compounds. This article reached its peak citation in 2018, with 4 citations. It has been cited in 13 different journals, 23% of which are open access. Among related journals, the Nature Reviews Drug Discovery cited this research the most, with 2 citations. The chart below illustrates the annual citation trends for this article.
Citations used this article by year