JCI Insight

Title Publication Date Language Citations
Tumor-draining lymph nodes are pivotal in PD-1/PD-L1 checkpoint therapy2018/12/06English202
The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense2019/02/21English201
Clinical and pathological investigation of patients with severe COVID-192020/06/18English195
Changes in body composition and weight during the menopause transition2019/03/07English193
Safety and efficacy of the JAK inhibitor tofacitinib citrate in patients with alopecia areata2016/09/22English192
TGF-β inhibition via CRISPR promotes the long-term efficacy of CAR T cells against solid tumors2020/02/27English192
Single-cell analysis of fate-mapped macrophages reveals heterogeneity, including stem-like properties, during atherosclerosis progression and regression2019/02/21English189
Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer2017/09/21English188
First-in-human topical microbiome transplantation with Roseomonas mucosa for atopic dermatitis2018/05/03English187
Oral ruxolitinib induces hair regrowth in patients with moderate-to-severe alopecia areata2016/09/22English184
Molecular characterization of the transition from acute to chronic kidney injury following ischemia/reperfusion2017/09/21English179
Frameshift events predict anti–PD-1/L1 response in head and neck cancer2018/02/22English174
Steroid metabolome analysis reveals prevalent glucocorticoid excess in primary aldosteronism2017/04/20English169
Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist2020/09/03English169
Tissue-specific metabolic reprogramming drives nutrient flux in diabetic complications2016/09/22English166
Redefined clinical features and diagnostic criteria in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy2016/08/18English166
Lipid abnormalities in atopic skin are driven by type 2 cytokines2018/02/22English165
Cytokine profile in plasma of severe COVID-19 does not differ from ARDS and sepsis2020/09/03English164
Telomere dysfunction in alveolar epithelial cells causes lung remodeling and fibrosis2016/09/08English162
Deep phenotyping of human induced pluripotent stem cell–derived atrial and ventricular cardiomyocytes2018/06/21English161
T cell receptor repertoire features associated with survival in immunotherapy-treated pancreatic ductal adenocarcinoma2018/07/12English160
Targeting the gut microbiome to treat the osteoarthritis of obesity2018/04/19English158
The senescence-associated secretome as an indicator of age and medical risk2020/06/18English158
A nanoparticle-incorporated STING activator enhances antitumor immunity in PD-L1–insensitive models of triple-negative breast cancer2018/11/15English158
Protection against Plasmodium falciparum malaria by PfSPZ Vaccine2017/01/12English157
Tumor-infiltrating B cells signal functional humoral immune responses in breast cancer2019/09/19English156
Pancreatic cancer therapy with combined mesothelin-redirected chimeric antigen receptor T cells and cytokine-armed oncolytic adenoviruses2018/04/05English156
Enhanced detection of neoantigen-reactive T cells targeting unique and shared oncogenes for personalized cancer immunotherapy2018/10/04English150
Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response2017/03/09English149
β Cell tone is defined by proglucagon peptides through cAMP signaling2019/03/07English147