JCI Insight

Title Publication Date Language Citations
Combining STING-based neoantigen-targeted vaccine with checkpoint modulators enhances antitumor immunity in murine pancreatic cancer2018/10/18English112
Global immune fingerprinting in glioblastoma patient peripheral blood reveals immune-suppression signatures associated with prognosis2018/11/02English112
Epigenetic regulation of macrophage polarization and inflammation by DNA methylation in obesity2016/11/17English112
Heme oxygenase-1 regulates mitochondrial quality control in the heart2016/02/25English112
Cytokinocytes: the diverse contribution of keratinocytes to immune responses in skin2020/10/15English111
Integrating molecular pathogenesis and clinical translation in sepsis-induced acute respiratory distress syndrome2019/01/24English111
Inhibition of Wnt/β-catenin signaling ameliorates osteoarthritis in a murine model of experimental osteoarthritis2018/02/08English110
Cystic fibrosis–related diabetes is caused by islet loss and inflammation2018/04/19English110
Endogenous retrovirus expression is associated with response to immune checkpoint pathway in clear cell renal cell carcinoma2018/08/23English110
Perfect timing: circadian rhythms, sleep, and immunity — an NIH workshop summary2020/01/16English110
Dual action of neurokinin-1 antagonists on Mas-related GPCRs2016/10/06English109
Anti-CD19 CAR T cells with high-dose melphalan and autologous stem cell transplantation for refractory multiple myeloma2018/04/19English109
Adiponectin/T-cadherin system enhances exosome biogenesis and decreases cellular ceramides by exosomal release2018/04/19English109
Assessing rejection-related disease in kidney transplant biopsies based on archetypal analysis of molecular phenotypes2017/06/15English109
Anti-SIRPα antibodies as a potential new tool for cancer immunotherapy2017/01/12English108
Human liver-kidney model elucidates the mechanisms of aristolochic acid nephrotoxicity2017/11/16English107
Interlesional diversity of T cell receptors in melanoma with immune checkpoints enriched in tissue-resident memory T cells2016/12/22English106
Neutrophil accumulation and NET release contribute to thrombosis in HIT2018/09/20English106
SGLT2 inhibitor dapagliflozin limits podocyte damage in proteinuric nondiabetic nephropathy2018/08/09English105
Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk2018/03/22English105
Synergy of radiotherapy and PD-1 blockade in Kras-mutant lung cancer2016/06/16English105
Low-dose IL-2 selectively activates subsets of CD4+ Tregs and NK cells2016/11/03English105
Intracellular localization of diacylglycerols and sphingolipids influences insulin sensitivity and mitochondrial function in human skeletal muscle2018/02/08English105
Heterogeneous antibodies against SARS-CoV-2 spike receptor binding domain and nucleocapsid with implications for COVID-19 immunity2020/09/17English104
Targeting protein disulfide isomerase with the flavonoid isoquercetin to improve hypercoagulability in advanced cancer2019/02/21English103
Neutralization of IL-8 decreases tumor PMN-MDSCs and reduces mesenchymalization of claudin-low triple-negative breast cancer2017/11/02English103
Neutrophil content predicts lymphocyte depletion and anti-PD1 treatment failure in NSCLC2019/12/19English102
Asfotase alfa therapy for children with hypophosphatasia2016/06/16English102
Tumor-specific MHC-II expression drives a unique pattern of resistance to immunotherapy via LAG-3/FCRL6 engagement2018/12/20English102
Signatures of CD8+ T cell dysfunction in AML patients and their reversibility with response to chemotherapy2018/11/02English102