JCI Insight

Title Publication Date Language Citations
Claudin-low bladder tumors are immune infiltrated and actively immune suppressed2016/03/17English147
PD-1hiCXCR5– T peripheral helper cells promote B cell responses in lupus via MAF and IL-212019/10/17English145
Microbiota, cirrhosis, and the emerging oral-gut-liver axis2017/10/05English144
Clinical implications of monitoring nivolumab immunokinetics in non–small cell lung cancer patients2018/10/04English144
PD-1 marks dysfunctional regulatory T cells in malignant gliomas2016/04/21English142
Inhibiting myeloid-derived suppressor cell trafficking enhances T cell immunotherapy2019/04/04English142
α-Synuclein in gut endocrine cells and its implications for Parkinson’s disease2017/06/15English142
Cardiac myosin-Th17 responses promote heart failure in human myocarditis2016/06/16English141
Continuous treatment with IL-15 exhausts human NK cells via a metabolic defect2018/02/08English141
An early-biomarker algorithm predicts lethal graft-versus-host disease and survival2017/02/09English140
Single cell RNA sequencing to dissect the molecular heterogeneity in lupus nephritis2017/05/04English140
Mesenchymal stromal cell exosomes prevent and revert experimental pulmonary fibrosis through modulation of monocyte phenotypes2019/11/01English140
Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade2021/01/25English138
Exosomes from mesenchymal stromal cells reduce murine colonic inflammation via a macrophage-dependent mechanism2019/12/19English136
A 3D microfluidic model for preclinical evaluation of TCR-engineered T cells against solid tumors2017/06/15English134
KLF2 and KLF4 control endothelial identity and vascular integrity2017/02/23English134
Glioblastoma-targeted CD4+ CAR T cells mediate superior antitumor activity2018/05/17English133
Foxp3 drives oxidative phosphorylation and protection from lipotoxicity2017/02/09English133
A simple protein-based surrogate neutralization assay for SARS-CoV-22020/10/02English132
Allosteric folding correction of F508del and rare CFTR mutants by elexacaftor-tezacaftor-ivacaftor (Trikafta) combination2020/09/17English132
Cellular heterogeneity during mouse pancreatic ductal adenocarcinoma progression at single-cell resolution2019/08/22English132
STAT6/Arg1 promotes microglia/macrophage efferocytosis and inflammation resolution in stroke mice2019/10/17English132
Dietary carbohydrate restriction improves metabolic syndrome independent of weight loss2019/06/20English131
SGLT2 inhibition reprograms systemic metabolism via FGF21-dependent and -independent mechanisms2019/03/07English131
Tumor cell oxidative metabolism as a barrier to PD-1 blockade immunotherapy in melanoma2019/03/07English131
Human angiotensin-converting enzyme 2 transgenic mice infected with SARS-CoV-2 develop severe and fatal respiratory disease2020/10/02English130
Inhibition of AKT signaling uncouples T cell differentiation from expansion for receptor-engineered adoptive immunotherapy2017/12/07English130
Renal protective effects of empagliflozin via inhibition of EMT and aberrant glycolysis in proximal tubules2020/03/26English129
Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis2016/04/21English129
ALS patients’ regulatory T lymphocytes are dysfunctional, and correlate with disease progression rate and severity2017/03/09English129