Xenobiotica

Title Publication Date Language Citations
Collagen gel immobilization: A useful cell culture technique for long-term metabolic studies on human hepatocytes1994/01/01English58
Absorption, distribution, metabolism, and excretion of macitentan, a dual endothelin receptor antagonist, in humans2012/03/30English58
CYP2D plays a major role in berberine metabolism in liver of mice and humans2011/07/25English58
The limited intestinal absorption via paracellular pathway is responsible for the low oral bioavailability of doxorubicin2012/12/19English57
The monooxygenases of birds, reptiles and amphibians1989/01/01English57
Interspecies scaling and prediction of human clearance: comparison of small- and macro-molecule drugs2011/09/05English57
Ethacrynic acid and its glutathione conjugate as inhibitors of glutathioneS-transferases1993/01/01English57
Molecular modelling of CYP3A4 from an alignment with CYP102: Identification of key interactions between putative active site residues and CYP3A-specific chemicals1996/01/01English57
Uptake, disposition, and persistence of nonylphenol from water in rainbow trout (Oncorhynchus mykiss)1996/01/01English57
Biliary excretion, metabolism and enterohepatic circulation of buprenorphine1981/01/01English57
N-Hydroxylation1971/01/01English57
The genetic polymorphism of sparteine metabolism1986/01/01English57
Metabolism, excretion and distribution of the flame retardant tetrabromobisphenol-A in conventional and bile-duct cannulated rats2000/01/01English57
Transdermal drug delivery and cutaneous metabolism1987/01/01English56
Metabolism of coumarin and 7-ethoxycoumarin by rat, mouse, guinea pig, Cynomolgus monkey and human precision-cut liver slices1994/01/01English56
Characterization of triptolide hydroxylation by cytochrome P450 in human and rat liver microsomes2008/11/21English56
Cytochrome P450: genotype to phenotype2019/08/14English56
A comparison of cardiomyocyte cytotoxic mechanisms for 5-fluorouracil and its pro-drug capecitabine2014/07/18English56
Microsomal metabolism of the terpene 1,8-cineole in the common brushtail possum (Trichosurus vulpecula), koala (Phascolarctos cinereus), rat and human2001/01/01English56
Multidrug resistance-associated protein 2 (MRP2) affects hepatobiliary elimination but not the intestinal disposition of tenofovir disoproxil fumarate and its metabolites2005/11/01English56
Biological fate of sulphur mustard, 1,1'-thiobis(2-chloroethane): isolation and identification of urinary metabolites following intraperitoneal administration to rat1992/01/01English55
Involvement of CYP2D6 in the in vitro metabolism of amphetamine, two N-alkylamphetamines and their 4-methoxylated derivatives1999/01/01English55
Identification of Three Sulphur-containing Urinary Metabolites of Styrene in the Rat1978/01/01English55
Modification of the erythrocyte anion carrier by chromate1985/01/01English55
Aspects of the metabolism of valproic acid1984/01/01English55
Challenges for blood–brain barrier (BBB) screening2007/11/01English55
Specificity of 17β-oestradiol and benzo[α]pyrene oxidation by polymorphic human cytochrome P4501B1 variants substituted at residues 48, 119 and 4322001/01/01English54
On the anticipation of the human dose in first-in-man trials from preclinical and prior clinical information in early drug development2007/11/01English54
Characterization of cytochrome P450 enzymes involved in drug oxidations in mouse intestinal microsomes2000/01/01English54
Effect of diet and nutrition on the expression of cytochromes P4501999/01/01English54