Xenobiotica

Title Publication Date Language Citations
CYP-catalysed cycling of clozapine and clozapine- N -oxide promotes the generation of reactive oxygen species in vitro2023/12/22English
Novel application of PBBM to justify impact of faster dissolution on safety and pharmacokinetics – a case study and utility in regulatory justifications2023/11/02English
Effect of tubeimoside I on the activity of cytochrome P450 enzymes in human liver microsomes2024/01/12English
Indirubin mediates adverse intestinal reactions in guinea pigs by downregulating the expression of AchE through AhR2024/01/08English
Chronic Toxoplasma infection affects gene expression of drug-metabolizing enzymes in mouse liver2023/11/02English
Population pharmacokinetics of mycophenolic acid and dose optimisation in adult Chinese kidney transplant recipients2023/11/02English
Comparative study on ABCB1-dependent efflux of anthracyclines and their metabolites: consequences for cancer resistance2023/07/03English
Empirical scaling factor for predicting human pharmacokinetic profiles of disproportionate metabolites using the Css–MRTpo method and chimeric mice with humanised livers2023/09/02English
Metabolite profiling and identification of enzymes responsible for the metabolism of hirsutine, a major alkaloid from Uncaria rhynchophylla2023/07/03English
Thank you to reviewers2024/01/02English
Preclinical pharmacokinetic investigation of the bioavailability and skin distribution of HY-072808 ointment, a novel drug candidate for the treatment of atopic dermatitis, in minipigs by a newly LC-MS/MS method2024/03/15English
Effects of pharmacogenetics on pharmacokinetics and toxicity of doxorubicin in Egyptian breast cancer patients2024/03/15English
Exploring the pharmacokinetics of second-generation cephalosporin, cefaclor: a systematic review in healthy and diseased populations2024/04/02English
The metabolism of the orexin-1 selective receptor antagonist nivasorexant2024/03/01English
Toxicokinetic and mass balance of morpholine in rats2023/05/04English
Meeting report: DMDG peptide and oligonucleotide ADME workshop 20222023/04/03English
Characterisation of UDP-glucuronosyltransferase activity in sea turtle Chelonia mydas2022/12/02English
Selection of a Suitable Animal Model to Evaluate Secretion of Drugs in the Human Milk: A Systematic Approach2024/04/18English
Preparation, characterisation, pharmacokinetics and distribution of esculin microspheres administered via intravitreal injection into rabbit brain2024/04/19English
Developmental stage and infection status may affect drug distribution in the prostate of rats2024/04/25English
Monomethyl Auristatin E (MMAE), a Payload for Multiple Antibody Drug Conjugates (ADCs), Demonstrates Differential Red Blood Cell Partitioning Across Human and Animal Species2024/04/22English
mRNA expression levels of cytochrome P450 CYP1A2 , CYP3A4 , and CYP3A5 in the epidermis: a focus on individual differences among Japanese individuals2024/04/24English
Exploring precision-cut liver slices for comparative xenobiotic metabolism profiling in swine and cattle2024/04/25English
Young scientists meet at Pfizer1999/01/01English
Investigation of the potential interaction between terfenadine and tedisamil in human liver microsomes1998/01/01English
Species differences in β-oxidative metabolism of a thromboxane A 2 -receptor antagonist [(+)-S-145] in rat, dog and monkey2001/03/01
Pharmacodynamic analysis between plasma level and inhibition of acid output after administration of a new histamine H2-receptor antagonist (Z-300) in dog2000/01/01English
Announcement1997/01/01English
Announcements1997/01/01English
Disposition of diphenyl sulphoxide in rat1998/01/01English