Xenobiotica

Title Publication Date Language Citations
Mechanism-based inactivation of human cytochrome P450 enzymes: strategies for diagnosis and drug–drug interaction risk assessment2007/11/01English54
The Metabolism of 3-Chloro-, 3-Bromo- and 3-Iodopropan-1,2-diol in Rats and Mice1975/01/01English54
Differences in the biotransformation of a 17β-hydroxylated steroid, trenbolone acetate, in rat and cow1981/01/01English54
Induction of cytochrome P450 isoenzymes in cultured precision-cut rat and human liver slices1996/01/01English54
Glutathione depletion: Its effects on other antioxidant systems and hepatocellular damage1991/01/01English54
Molecular modelling of CYP1A subfamily members based on an alignment with CYP102: rationalization of CYP1A substrate specificity in terms of active site amino acid residues1996/01/01English54
Pharmacological significance of the species differences in bupropion metabolism1987/01/01English54
Metabolism of nabumetone (BRL 14777) by various species including man1984/01/01English54
Three-dimensional models of human and other mammalian microsomal P450s constructed from an alignment with P450102 (P450bm3)1995/01/01English53
In vivoSuppression of Benzene and Styrene Oxidation by Co-administered Toluene in Rats and Effects of Phenobarbital1972/01/01English53
Pharmacokinetic and Metabolic Studies of the Hypoxic Cell Radiosensitizer Misonidazole1978/01/01English53
A species difference in the presystemic metabolism of carbazeran in dog and man1984/01/01English53
Interindividual and interspecies variation in the metabolism of the hallucinogen 4-methoxyamphetamine1979/01/01English53
Plasma protein binding of ceftriaxone1987/01/01English53
β-Apo-8′-carotenal, but not β-carotene, is a strong inducer of liver cytochromes P4501A1 and 1A2 in rat1996/01/01English53
Cytochrome P-450-dependent formation of reactive oxygen radicals: isozyme-specific inhibition of P-450-mediated reduction of oxygen and carbon tetrachloride1990/01/01English53
Potent and selective inhibition of magnolol on catalytic activities of UGT1A7 and 1A92012/05/16English53
Studies on the Metabolism of Ethynylestradiolin vitroandin vivo: The Significance of 2-Hydroxylation and the Formation of Polar Products1973/01/01English53
Separation of multiple forms of glutathioneS-transferase from the Blue Mussel,Mytilus edulis1993/01/01English53
A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 genein vitro1999/01/01English52
The Metabolism of Vanillin and Isovanillin in the Rat1975/01/01English52
Microbial cleavage of zearalenone1988/01/01English52
Functional involvement of organic cation transporter1 (OCT1/Oct1) in the hepatic uptake of organic cations in humans and rats2007/08/01English52
Identification of cytochrome P450 forms involved in the 4-hydroxylation of valsartan, a potent and specific angiotensin II receptor antagonist, in human liver microsomes2005/06/01English51
Method for predicting the risk of drug–drug interactions involving inhibition of intestinal CYP3A4 and P-glycoprotein2009/06/01English51
Human-liver cytochromes P-450 involved in polymorphisms of drug oxidation1986/01/01English51
Metabolism of Chlorodiphenyl Ethers and Irgasan® DP 3001979/01/01English51
Metabolic aspects of antioxidants and preservatives1986/01/01English51
The reduction of sulphinpyrazone and sulindac by intestinal bacteria1987/01/01English51
Terpenoid biotransformation in mammals IV Biotransformation of (+)-longifolene, (-)-caryophyllene, (-)-caryophyllene oxide, (-)-cyclocolorenone, (+)-nootkatone, (-)-elemol, (-)-abietic acid and (+)-dehydroabietic acid in rabbits1986/01/01English50