Xenobiotica

Title Publication Date Language Citations
The Disposition and Metabolism of Flurbiprofen in Several Species Including Man1978/01/01English62
Human dose-excretion studies with the pyrethroid insecticide, cypermethrin1983/01/01English62
Pharmacokinetics and metabolism of BIBF 1120 after oral dosing to healthy male volunteers2011/01/04English62
Metabolism of Atenolol in Man1978/01/01English62
The interaction of representative members from two classes of antimycotics—the azoles and the allylamines—with cytochromes P-450 in steroidogenic tissues and liver1985/01/01English62
Methylation protects dietary flavonoids from rapid hepatic metabolism2006/05/01English62
Drug-metabolizing activity of human and rat liver, lung, kidney and intestine slices2002/01/01English62
Molecular modelling of cytochrome P4502D6 (CYP2D6) based on an alignment with CYP102 : structural studies on specific CYP2D6substrate metabolism1997/01/01English62
Application of PBPK modelling in drug discovery and development at Pfizer2011/10/30English62
Altered Activity of Hepatic Mixed-Function Monooxygenase Enzymes in Streptozotocin-induced Diabetic Rats1978/01/01English61
Metabolism of some naturally occurring isothiocyanates in the rat1983/01/01English61
Reliability of human cryopreserved hepatocytes and liver microsomes asin vitrosystems to predict metabolic clearance2008/10/01English61
Cytotoxicity and cytoprotective activities of natural compounds. The case of curcumin1996/01/01English60
Homology modelling of human CYP2 family enzymes based on the CYP2C5 crystal structure2002/01/01English60
Studies on the induction of rat hepatic CYP1A, CYP2B, CYP3A and CYP4A subfamily form mRNAs in vivo and in vitro using precision-cut rat liver slices2003/01/01English60
The biliary and urinary metabolites of [3H]17α-ethynylestradiol in women1983/01/01English59
Characterization and induction of xenobiotic metabolizing enzyme activities in a primary culture of rainbow trout hepatocytes1991/01/01English59
The Metabolic Fate of Prazosin1977/01/01English59
In vivo metabolism of diallyl disulphide in the rat: identification of two new metabolites2002/01/01English59
SLC28 genes and concentrative nucleoside transporter (CNT) proteins2008/08/01English59
Stereoselectivity of ibuprofen metabolism and pharmacokinetics following the administration of the racemate to healthy volunteers2002/01/01English59
Regional and cellular distribution of CYP2D subfamily members in rat brain2000/01/01English59
Comprehensive preclinical pharmacokinetic evaluations of trastuzumab deruxtecan (DS-8201a), a HER2-targeting antibody-drug conjugate, in cynomolgus monkeys2019/01/04English59
Effects of arachidonic acid, prostaglandins, retinol, retinoic acid and cholecalciferol on xenobiotic oxidations catalysed by human cytochrome P450 enzymes1999/01/01English59
Cytochrome P450 isozymes responsible for the metabolism of toluene and styrene in human liver microsomes1997/01/01English59
Ritonavir and dexamethasone induce expression of CYP3A and P-glycoprotein in rats2004/02/01English58
Structural and functional integrity of precision-cut liver slices in xenobiotic metabolism: a comparison of the dynamic organ and multiwell plate culture procedures1999/01/01English58
Role of hepatic metabolism in the bioactivation and detoxication of amodiaquine1995/01/01English58
Prediction of metabolic drug clearance in humans:In vitro–in vivoextrapolationvsallometric scaling2006/07/01English58
A review of the methods of chemical synthesis of sulphate and glucuronide conjugates1987/01/01English58