Nature Methods

Title Publication Date Language Citations
Fluorescence microscopy2005/11/18English966
Proteoform: a single term describing protein complexity2013/02/27English965
MiXCR: software for comprehensive adaptive immunity profiling2015/04/29English955
Direct detection of DNA methylation during single-molecule, real-time sequencing2010/05/09English946
miRWalk2.0: a comprehensive atlas of microRNA-target interactions2015/07/30English932
Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture2015/05/25English932
Next-generation sequencing transforms today's biology2007/12/19English931
Evaluation of fluorophores for optimal performance in localization-based super-resolution imaging2011/11/06English923
Chemically defined conditions for human iPSC derivation and culture2011/04/10English921
Three-dimensional culture models of normal and malignant breast epithelial cells2007/03/29English916
U-Net: deep learning for cell counting, detection, and morphometry2018/12/17English914
Error-correcting barcoded primers for pyrosequencing hundreds of samples in multiplex2008/02/10English913
Icy: an open bioimage informatics platform for extended reproducible research2012/06/28English907
Genetically encoded fluorescent indicator for intracellular hydrogen peroxide2006/03/22English907
Improved whole-chromosome phasing for disease and population genetic studies2013/01/01English897
Analysis and design of RNA sequencing experiments for identifying isoform regulation2010/11/07English893
Species-level functional profiling of metagenomes and metatranscriptomes2018/10/30English891
Sensitive protein alignments at tree-of-life scale using DIAMOND2021/04/01English891
Genome-wide profiles of STAT1 DNA association using chromatin immunoprecipitation and massively parallel sequencing2007/06/11English885
Selected reaction monitoring–based proteomics: workflows, potential, pitfalls and future directions2012/05/30English879
Prevention of overfitting in cryo-EM structure determination2012/07/29English862
Differential analysis of RNA-seq incorporating quantification uncertainty2017/06/05English856
Cellpose: a generalist algorithm for cellular segmentation2020/12/14English852
RNA-guided gene activation by CRISPR-Cas9–based transcription factors2013/07/25English851
Contrast agents for molecular photoacoustic imaging2016/07/28English848
Moving beyond P values: data analysis with estimation graphics2019/06/19English831
Single-cell mRNA quantification and differential analysis with Census2017/01/23English816
High-density mapping of single-molecule trajectories with photoactivated localization microscopy2008/01/13English813
Detecting overlapping protein complexes in protein-protein interaction networks2012/03/18English811
SC3: consensus clustering of single-cell RNA-seq data2017/03/27English807