JCI Insight

Title Publication Date Language Citations
Personalized therapy for lung cancer: Striking a moving target2018/08/09English91
Canagliflozin triggers the FGF23/1,25-dihydroxyvitamin D/PTH axis in healthy volunteers in a randomized crossover study2018/04/19English91
Development of MK-8353, an orally administered ERK1/2 inhibitor, in patients with advanced solid tumors2018/02/22English91
Fibroblast activation protein augments progression and metastasis of pancreatic ductal adenocarcinoma2017/10/05English91
Altered X-chromosome inactivation in T cells may promote sex-biased autoimmune diseases2019/04/04English91
Tet2-mediated clonal hematopoiesis in nonconditioned mice accelerates age-associated cardiac dysfunction2020/03/26English90
Piezo1 incorporates mechanical force signals into the genetic program that governs lymphatic valve development and maintenance2019/03/07English90
Heart-resident CCR2+ macrophages promote neutrophil extravasation through TLR9/MyD88/CXCL5 signaling2016/08/04English90
Impaired ketogenesis and increased acetyl-CoA oxidation promote hyperglycemia in human fatty liver2019/06/06English90
Commensal bacteria stimulate antitumor responses via T cell cross-reactivity2020/04/23English89
A wearable artificial kidney for patients with end-stage renal disease2016/06/02English89
CX3CR1 identifies PD-1 therapy–responsive CD8+ T cells that withstand chemotherapy during cancer chemoimmunotherapy2018/04/19English89
Development of an in vitro human liver system for interrogating nonalcoholic steatohepatitis2016/12/08English89
Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich’s ataxia cardiomyopathy model2017/07/20English89
Large-scale plasma lipidomic profiling identifies lipids that predict cardiovascular events in secondary prevention2018/09/06English89
Exosome-delivered microRNAs promote IFN-α secretion by human plasmacytoid DCs via TLR72018/05/17English88
Contribution of plasma cells and B cells to hidradenitis suppurativa pathogenesis2020/10/02English88
Diverse cellular architecture of atherosclerotic plaque derives from clonal expansion of a few medial SMCs2017/10/05English87
Plasma vesicle miRNAs for therapy response monitoring in Hodgkin lymphoma patients2016/11/17English87
Optimized multiplex immunofluorescence single-cell analysis reveals tuft cell heterogeneity2017/06/02English87
Mature neutrophils suppress T cell immunity in ovarian cancer microenvironment2019/03/07English87
Mitophagy-dependent macrophage reprogramming protects against kidney fibrosis2019/12/05English87
High dietary salt–induced DC activation underlies microbial dysbiosis-associated hypertension2019/07/11English86
Mast cells and neutrophils mediate peripheral motor pathway degeneration in ALS2018/10/04English86
Compensation between CSF1R+ macrophages and Foxp3+ Treg cells drives resistance to tumor immunotherapy2018/06/07English86
Glycolytic requirement for NK cell cytotoxicity and cytomegalovirus control2017/12/07English85
Monitoring liver damage using hepatocyte-specific methylation markers in cell-free circulating DNA2018/06/21English85
Chronic cigarette smoke exposure induces systemic hypoxia that drives intestinal dysfunction2018/02/08English85
Lung vaso-occlusion in sickle cell disease mediated by arteriolar neutrophil-platelet microemboli2017/01/12English85
Human pericytes adopt myofibroblast properties in the microenvironment of the IPF lung2017/12/21English84