ASSAY and Drug Development Technologies

Title Publication Date Language Citations
Impedance-Based Detection of Beating Rhythm and Proarrhythmic Effects of Compounds on Stem Cell-Derived Cardiomyocytes2011/12/01English73
Drug Discovery Approaches Utilizing Three-Dimensional Cell Culture2016/02/01English73
Label-Free Cytotoxicity Screening Assay by Digital Holographic Microscopy2013/03/01English71
The Cellular Distribution of Fluorescently Labeled Arrestins Provides a Robust, Sensitive, and Universal Assay for Screening G Protein-Coupled Receptors2002/11/01English70
High-Content Assay to Identify Inhibitors of Dengue Virus Infection2010/10/01English68
Phenotypic Characterization of Toxic Compound Effects on Liver Spheroids Derived from iPSC Using Confocal Imaging and Three-Dimensional Image Analysis2016/09/01English67
The Zebrafish: A Powerful Platform forIn Vivo, HTS Drug Discovery2011/08/01English67
Primary Cells and Stem Cells in Drug Discovery: Emerging Tools for High-Throughput Screening2011/04/01English67
Computational and Practical Aspects of Drug Repositioning2015/07/01English66
Enzyme Fragment Complementation: A Flexible High Throughput Screening Assay Technology2002/11/01English64
Characterization of Potassium Channel Modulators with QPatch™ Automated Patch-Clamp Technology: System Characteristics and Performance2003/10/01English64
Detection of High- and Low-Affinity Antibodies Against a Human Monoclonal Antibody Using Various Technology Platforms2007/10/01English64
Characterization of Selective Ubiquitin and Ubiquitin-Like Protease Inhibitors Using a Fluorescence-Based Multiplex Assay Format2011/04/01English63
Biophysical Methods for Monitoring Cell-Substrate Interactions in Drug Discovery2003/06/01English61
Capture Compound Mass Spectrometry: A Technology for the Investigation of Small Molecule Protein Interactions2007/06/01English60
The XTT Cell Proliferation Assay Applied to Cell Layers Embedded in Three-Dimensional Matrix2012/08/01English60
Kinetic Exclusion Assay Technology: Characterization of Molecular Interactions2004/12/01English60
How to Triage PAINS-Full Research2016/04/01English60
Assay Development for Histone Methyltransferases2013/05/01English60
Activity of Anticancer Agents in a Three-Dimensional Cell Culture Model2010/10/01English59
Simultaneous Measurement of 10,000 Protein-Ligand Affinity Constants Using Microarray-Based Kinetic Constant Assays2012/06/01English59
Identification of HumanEther-à-go-goRelated Gene Modulators by Three Screening Platforms in an Academic Drug-Discovery Setting2010/12/01English58
High Throughput Ion-Channel Pharmacology: Planar-Array-Based Voltage Clamp2003/02/01English58
Rat Primary Hepatocytes Show Enhanced Performance and Sensitivity to Acetaminophen During Three-Dimensional Culture on a Polystyrene Scaffold Designed for Routine Use2011/10/01English58
Emerging Concepts of Guanine Nucleotide-Binding Protein-Coupled Receptor (GPCR) Function and Implications for High Throughput Screening2007/06/01English58
The Current Status of Drug Discovery Against the Human Kinome2009/02/01English57
Functional Assay of Voltage-Gated Sodium Channels Using Membrane Potential-Sensitive Dyes2004/06/01English57
Automated Tight Seal Electrophysiology for Assessing the Potential hERG Liability of Pharmaceutical Compounds2004/10/01English56
Action Potential Characterization of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes Using Automated Patch-Clamp Technology2014/10/01English56
Rapid Structure-Activity and Selectivity Analysis of Kinase Inhibitors by BioMAP Analysis in Complex Human Primary Cell-Based Models2004/08/01English56