ASSAY and Drug Development Technologies

Title Publication Date Language Citations
Three-Dimensional Cell Culture Systems and Their Applications in Drug Discovery and Cell-Based Biosensors2014/05/01English1,537
Molecular Interaction Studies Using Microscale Thermophoresis2011/08/01English565
Application of Real-Time Cell Electronic Sensing (RT-CES) Technology to Cell-Based Assays2004/08/01English282
Bioluminescent Assays for High-Throughput Screening2007/02/01English278
Zebrafish: A Preclinical Model for Drug Screening2002/11/01English272
Improving the Solubility and Pharmacological Efficacy of Curcumin by Heat Treatment2007/08/01English245
Use of Multiple Assay Endpoints to Investigate the Effects of Incubation Time, Dose of Toxin, and Plating Density in Cell-Based Cytotoxicity Assays2004/02/01English199
Extracellular Matrix Remodeling: The Common Denominator in Connective Tissue DiseasesPossibilities for Evaluation and Current Understanding of the Matrix as More Than a Passive Architecture, but a Key Player in Tissue Failure2013/03/01English195
ADP-Glo: A Bioluminescent and Homogeneous ADP Monitoring Assay for Kinases2009/12/01English183
Label-Free Cell-Based Assays with Optical Biosensors in Drug Discovery2006/10/01English140
Dynamic and Label-Free Cell-Based Assays Using the Real-Time Cell Electronic Sensing System2006/10/01English128
A FRET-Based Assay Platform for Ultra-High Density Drug Screening of Protein Kinases and Phosphatases2002/11/01English125
High-Content Assays for Characterizing the Viability and Morphology of 3D Cancer Spheroid Cultures2015/09/01English124
Advances in High Content Screening for Drug Discovery2003/08/01English121
Identification and Characterization of Pharmacological Chaperones to Correct Enzyme Deficiencies in Lysosomal Storage Disorders2011/06/01English118
A High Throughput Luminescent Assay for Glycogen Synthase Kinase-3β Inhibitors2007/02/01English102
AlphaLISA Immunoassay Platform— The “No-Wash” High-Throughput Alternative to ELISA2009/02/01English102
Thermal Denaturation Assays in Chemical Biology2012/04/01English96
High-Throughput Screening with Quantitation of ATP Consumption: A Universal Non-Radioisotope, Homogeneous Assay for Protein Kinase2004/04/01English94
High-Content Assay Multiplexing for Toxicity Screening in Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Hepatocytes2015/11/01English89
High-Content Assays for Hepatotoxicity Using Induced Pluripotent Stem Cell–Derived Cells2014/01/01English87
Development of a 384-Well Colorimetric Assay to Quantify Hydrogen Peroxide Generated by the Redox Cycling of Compounds in the Presence of Reducing Agents2008/08/01English87
A Robotic Platform for Quantitative High-Throughput Screening2008/10/01English86
High Throughput Assay Technologies for Ion Channel Drug Discovery2004/10/01English83
In Vitro, Ex Vivo, andIn VivoMethodological Approaches for Studying Therapeutic Targets of Osteoporosis and Degenerative Joint Diseases: How Biomarkers Can Assist?2005/10/01English82
An Automated Liquid Chromatography-Mass Spectrometry Process to Determine Metabolic Stability Half-Life and Intrinsic Clearance of Drug Candidates by Substrate Depletion2008/02/01English79
Profiling the NIH Small Molecule Repository for Compounds That Generate H2O2by Redox Cycling in Reducing Environments2010/04/01English79
Scintillation Proximity Assays in High-Throughput Screening2008/06/01English77
HTS Identifies Novel and Specific Uncompetitive Inhibitors of the Two-Component NS2B-NS3 Proteinase of West Nile Virus2007/12/01English76
High Throughput Screening Technologies for Direct Cyclic AMP Measurement2003/04/01English74