Are biofilms the key to understanding chronic infections? This review synthesizes our current understanding of biofilms, complex communities of surface-associated cells encased in a protective polymer matrix. It emphasizes the importance of understanding biofilm structure and function to combat antimicrobial resistance. The review highlights the mechanisms by which microorganisms within biofilms achieve high resistance to antimicrobial agents and discusses the association of biofilms with various human diseases, such as native valve endocarditis and cystic fibrosis. It also addresses the role of biofilms in colonizing medical devices. By outlining the processes by which biofilm-associated microorganisms elicit disease, such as cell detachment, endotoxin production, and immune system resistance, this review underscores the need for effective prevention and control strategies. These strategies range from preventing initial device colonization to inhibiting genes involved in biofilm formation, offering potential future treatment approaches.
Published in Clinical Microbiology Reviews, this paper provides a comprehensive overview of biofilms, a topic of significant importance in clinical microbiology. By synthesizing current knowledge and highlighting clinical implications, the paper aligns with the journal's mission to provide in-depth, authoritative reviews of critical topics in the field.
| Category | Category Repetition |
|---|---|
| Science: Microbiology | 61 |
| Technology: Chemical technology: Biotechnology | 29 |
| Science: Chemistry | 12 |
| Science: Biology (General) | 10 |
| Medicine | 10 |