Can stem cells revolutionize the repair of complex facial injuries? This comprehensive review explores the use of mesenchymal stem cells (MSCs) in craniofacial reconstruction, addressing challenges like complexity, specificity, and wound irregularities. Traditionally, tissue transplantation has been the standard approach, but it often yields suboptimal results due to the unique origin and structure of craniofacial bones. Autologous MSC transplantation, with its excellent pluripotency, low immunogenicity, and minimally invasive nature, emerges as a promising alternative. Researchers have observed significant effects of both craniofacial-specific MSCs and MSCs from other body parts in restoring craniofacial bones, cartilage, wounds, and adipose tissue. The study also highlights the role of tissue engineering in providing innovative solutions for craniofacial repair. As research into MSCs and tissue engineering advances, autologous MSC transplantation gains increasing acceptance for craniofacial reconstruction. This review consolidates the current understanding of MSC applications, offering valuable insights for future research and clinical practices in regenerative medicine.
Published in Frontiers in Molecular Biosciences, this review aligns with the journal's focus on molecular-level investigations of biological processes. By examining the applications of mesenchymal stem cells in craniofacial reconstruction at a molecular level, the research contributes to the understanding of regenerative medicine and tissue engineering, key areas within the journal's scope. The review also emphasizes the pluripotency and molecular mechanisms of stem cells, further strengthening its relevance to the journal.
| Category | Category Repetition |
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| Medicine: Medicine (General) | 67 |
| Science: Biology (General) | 48 |
| Science: Biology (General): Genetics | 40 |
| Technology: Chemical technology: Biotechnology | 26 |