Can quantum mechanics enhance our understanding of enzyme behavior? This review explores methods for incorporating quantum mechanical effects into enzyme kinetics simulations, where the enzyme is explicitly included in the model. The review focuses on three key aspects: the use of quantum mechanical electronic structure methods (molecular orbital theory and density functional theory), treating vibrational motions quantum mechanically (harmonic approximation, path integrals, or a three-dimensional wave function coupled to classical nuclear motion), and incorporating multidimensional tunneling approximations into reaction rate calculations. These approaches aim to provide a more accurate description of enzyme kinetics by accounting for quantum phenomena that classical simulations often neglect. This comprehensive review provides valuable insights into the use of quantum mechanical methods in enzyme kinetics, guiding future research in this field.