How do cells rapidly translate extracellular signals into action? This review investigates the Jak-STAT pathway, a crucial signaling cascade activated by cytokines and interferons to regulate diverse cellular functions in the lympho-hematopoietic system. The pathway is important in the regulation of cellular functions in the lympho-hematopoietic system. This work explores the rapid transduction of extracellular signals into the nucleus via the Jak-STAT pathway. It elucidates the mechanism by which Janus family tyrosine kinases (Jaks) tyrosine phosphorylate signal transducers and activators of transcription (STATs), enabling STAT protein dimerization and nuclear translocation, which modulates target gene expression. It also covers the range of known Jaks and STATs, including the range of known Jaks and STATs, and discusses defects observed in animals and humans lacking some of these signaling molecules. By exploring the biological implications of this pathway, this review contributes to understanding immune responses and cellular regulation, potentially informing therapeutic strategies for immune-related disorders.
Appearing in the Annual Review of Immunology, this paper on JAKs and STATs directly addresses a core topic in the field of immunology. The review's comprehensive overview of the Jak-STAT pathway and its role in immune signaling aligns with the journal's mission to provide authoritative summaries of key developments in immunology.