How does gp130 mediate the diverse effects of the interleukin-6 family of cytokines? This review examines the role of gp130, a common signal-transducing receptor component, in mediating the biological functions of the interleukin-6 family of cytokines. Understanding these signaling pathways is crucial for comprehending immune and hematopoietic regulation. The review discusses how receptors for interleukins and cytokines in the class I cytokine receptor family form multichain complexes. The interleukin-6 family of cytokines, including interleukin-6, interleukin-11, and leukemia inhibitory factor, all share gp130 as a critical component for signal transduction. Stimulation of cells with these cytokines triggers homo- or heterodimerization of gp130, leading to activation of cytoplasmic tyrosine kinases and subsequent modification of transcription factors. This paper provides a comprehensive overview of recent advances in understanding the interleukin-6 family of cytokines and gp130 signaling. Further research could explore the therapeutic potential of targeting these pathways in various diseases.
Published in the Annual Review of Immunology, this research aligns perfectly with the journal's focus on immunology and cytokine biology. The study's detailed examination of gp130 and its role in interleukin-6 signaling directly contributes to the journal's core themes.