Unraveling the intricacies of immune cell communication: This review article provides a comprehensive understanding of the interferon-gamma (IFNγ) receptor and its role in signal transduction. It highlights the significant progress made in elucidating the molecular mechanisms underlying IFNγ-induced cellular responses, establishing a nearly complete model of IFNγ signaling. This review covers the structure and function of the IFNγ receptor, detailing the mechanism of IFNγ signal transduction and validating the physiological relevance of this process. The authors emphasize the molecular events linking receptor ligation to signal transduction, offering valuable insights into the comprehensive model of IFNγ signaling. This research serves as a paradigm for understanding signaling by other members of the cytokine receptor superfamily. By defining the IFNγ receptor's role, this paper provides a foundational framework for future immunological studies and potential therapeutic interventions.
Appearing in the Annual Review of Immunology, this article is highly relevant due to the journal's focus on providing comprehensive overviews of key topics in immunology. The review’s in-depth analysis of the IFNγ receptor and its signaling pathways aligns perfectly with the journal’s mission to present timely and authoritative syntheses of important advances in the field.