What are the unique characteristics and functions of mouse CD1-specific NK1 T cells? This review examines these specialized T cells, which express NK lineage receptors and rapidly secrete large amounts of cytokines. Their unique potential provides early help for effector cells and regulates Th1 or Th2 differentiation of immune responses. NK1 T cells have a restricted TCR repertoire consisting of an invariant TCR α chain and polyclonal Vβ8, Vβ7, and Vβ2 TCR β chains. These cells recognize products of the CD1 gene family, seemingly without foreign antigens, bridging innate and adaptive immunity. This regulatory pathway's activation doesn't require antigen recognition. This review provides a thorough overview of mouse NK1 T cell specificity and function, exploring their relationship to mainstream T cells and NK cells. Understanding this unique cell population and its role in immune regulation may have significant implications for developing novel immunotherapies.
Published in the _Annual Review of Immunology_, this article is a comprehensive overview of a specific area within immunology, aligning perfectly with the journal's mission to provide in-depth reviews of key topics in the field. The focus on NK1 T cells and their role in immune regulation contributes valuable insights for researchers in immunology and related disciplines.
| Category | Category Repetition |
|---|---|
| Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy | 626 |
| Medicine: Medicine (General) | 233 |
| Medicine | 72 |
| Science: Biology (General) | 69 |
| Science: Science (General) | 64 |