How do cells maintain their structural integrity and function within tissues? This comprehensive review explores the genetic and molecular mechanisms that govern epithelial cell polarity and cell junctions in *Drosophila*. This research provides a detailed understanding of these fundamental processes in a whole animal model system. The review highlights the crucial role of protein complexes assembled around transmembrane proteins such as DE-cadherin, Crumbs, and Neurexin IV, as well as cytoplasmic protein complexes associated with the plasma membrane. These complexes control the asymmetry of the plasma membrane, the differentiation of membrane domains, and the formation of cellular junctions. While significant progress has been made, much remains to be learned about how these complexes assemble, establish their polarized distribution, and contribute to the asymmetric organization of epithelial cells. Further research in this area promises to yield valuable insights into the development and maintenance of tissue architecture and function.
Published in the Annual Review of Genetics, this review provides a comprehensive overview of epithelial cell polarity and cell junctions in Drosophila, aligning with the journal's broad scope of genetic and molecular biology. The synthesis of current knowledge and identification of remaining questions contribute to the advancement of genetic research.
| Category | Category Repetition |
|---|---|
| Science: Biology (General): Genetics | 231 |
| Science: Biology (General): Cytology | 216 |
| Science: Biology (General) | 172 |
| Science: Chemistry: Organic chemistry: Biochemistry | 59 |
| Science: Science (General) | 30 |