How does translational control orchestrate early embryonic development in *Drosophila*? This review examines the prevalent role of translational regulation during oogenesis and embryogenesis. Maternal mRNAs are localized within the oocyte, often coupled with translational regulation, to direct early embryonic stages. The review outlines general mechanisms of translational regulation and mRNA localization found across various model systems. It then focuses on the posttranscriptional regulation of four key maternal transcripts in *Drosophila*: *bicoid* (*bcd*), *nanos* (*nos*), *oskar* (*osk*), and *gurken* (*grk*). Cis- and trans-acting factors involved in localization and translational control are discussed. The authors discuss potential regulatory mechanisms related to four maternal transcripts: bicoid (bcd), nanos (nos), oskar (osk), and gurken (grk). Cis- and trans-acting factors required for the localization and translational control of these mRNAs are discussed along with potential mechanisms for their regulation. This comprehensive overview is invaluable for researchers in **genetics**, **developmental biology**, and **molecular biology**.
As a review published in Annual Review of Genetics, this article aligns with the journal’s focus on providing comprehensive overviews of key topics in genetics. The paper’s exploration of translational regulation and RNA localization during Drosophila development contributes to the broader understanding of gene expression, a central theme in genetics.
| Category | Category Repetition |
|---|---|
| Science: Biology (General): Genetics | 138 |
| Science: Biology (General) | 137 |
| Science: Biology (General): Cytology | 117 |
| Science: Chemistry: Organic chemistry: Biochemistry | 44 |
| Science: Science (General) | 13 |