What if our genetic code isn't always what it seems? This review explores the fascinating world of RNA editing, where specific alterations in RNA sequences occur after transcription. This process, found in organisms ranging from protozoa to humans, influences mRNAs, tRNAs, and rRNAs across all cellular compartments. The review highlights the diverse mechanisms involved in RNA editing, encompassing nucleotide insertion, deletion, and base conversion. Recent advances in in vitro editing and transgenic systems offer insights into the biochemical strategies, regulatory sequences, and cellular factors driving these modifications. Understanding the functions and mechanisms of RNA editing provides insights into gene expression regulation. By highlighting the range of editing mechanisms and the factors involved, this review lays the foundation for further research into the roles of RNA editing in various biological processes.
This review, published in the Annual Review of Genetics, explores the functions and mechanisms of RNA editing, which is directly aligned with the journal’s core focus on genetics and genomics. By presenting an overview of diverse RNA editing mechanisms and their regulatory implications, the review adds to the understanding of gene expression and its role in cellular processes.
| Category | Category Repetition |
|---|---|
| Science: Biology (General) | 121 |
| Science: Biology (General): Genetics | 103 |
| Science: Chemistry: Organic chemistry: Biochemistry | 79 |
| Science: Biology (General): Cytology | 38 |
| Science: Science (General) | 30 |