Unraveling the complexity of life's building blocks: This review delves into the intricate process of ribosome synthesis in the yeast *Saccharomyces cerevisiae*. Highlighting recent advances, the authors reveal that functional eukaryotic ribosome synthesis requires a surprisingly large number of trans-acting factors, far beyond the 75 individual ribosomal proteins and 4 ribosomal RNAs. This underscores the remarkable complexity underlying this fundamental cellular process. In addition to around 75 individual ribosomal proteins and 4 ribosomal RNAs, synthesis of a functional eukaryotic ribosome requires a remarkable number of trans-acting factors. Here, we will discuss the recent, and often surprising, advances in our understanding of ribosome synthesis in the yeast Saccharomyces cerevisiae. These new data will underscore the unexpected complexity of eukaryotic ribosome synthesis. By providing a comprehensive overview of the latest discoveries, this review serves as a valuable resource for researchers seeking to understand the intricacies of ribosome biogenesis.
Published in the Annual Review of Genetics, this article aligns perfectly with the journal's focus on providing comprehensive reviews of significant advances in genetics. The detailed examination of ribosome synthesis in Saccharomyces cerevisiae contributes to the understanding of fundamental cellular processes, reflecting the journal's commitment to disseminating knowledge in this critical area of biological science.
| Category | Category Repetition |
|---|---|
| Science: Biology (General) | 311 |
| Science: Biology (General): Genetics | 246 |
| Science: Chemistry: Organic chemistry: Biochemistry | 196 |
| Science: Biology (General): Cytology | 155 |
| Science: Science (General) | 37 |