Unlocking the secrets of mammalian genetics, this review focuses on genomic imprinting, a phenomenon where certain autosomal genes are inherited silently from one parent but actively expressed from the other. This results in functional hemizygosity for imprinted genes. The paper highlights that allele-specific methylation of CpG residues, established in germlines and maintained during embryogenesis, plays a key role in maintaining imprinting in somatic cells. With a focus on 19 identified imprinted genes, the research explores the expression patterns from maternal and paternal chromosomes. This work delves into the mechanisms that maintain imprinting and its significance in regulating fetal growth. This work has significant implications for developmental biology and genetic research, furthering our understanding of mammalian development. Genomic imprinting's role in fetal development warrants further investigation. The study highlights the importance of allele-specific methylation in maintaining imprinting, setting the stage for future research into the functional significance and evolutionary origins of genomic imprinting.
The Annual Review of Genetics covers major advancements in genetics research. This paper on genomic imprinting is highly relevant, offering a comprehensive overview of the mechanisms and functions of imprinted genes in mammals. The review synthesizes existing knowledge, making it a valuable resource for researchers in genetics and developmental biology.
| Category | Category Repetition |
|---|---|
| Science: Biology (General): Genetics | 169 |
| Science: Biology (General) | 146 |
| Medicine: Medicine (General) | 75 |
| Science: Biology (General): Cytology | 72 |
| Science: Chemistry: Organic chemistry: Biochemistry | 46 |