Soft Lithography in Biology and Biochemistry

Article Properties
  • Language
    English
  • DOI (url)
    10.1146/annurev.bioeng.3.1.335
  • Publication Date
    2001/08/01
  • Journal
    Annual Review of Biomedical Engineering
  • Indian UGC (Journal)
  • Refrences
    230
  • Citations
    1,811
  • George M. Whitesides Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138,Surface Logix Inc., 50 Soldiers Field Place, Brighton, MA 02135.Department of Biomedical Engineering, University of Michigan, 2350 Hayward, 3304 GG Brown, Ann Arbor, Michigan 48109-2125.Departments of Surgery and Pathology, Children's Hospital and Harvard Medical School, Enders 1007, Boston, Massachusetts 02115;
  • Emanuele Ostuni Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138,Surface Logix Inc., 50 Soldiers Field Place, Brighton, MA 02135.Department of Biomedical Engineering, University of Michigan, 2350 Hayward, 3304 GG Brown, Ann Arbor, Michigan 48109-2125.Departments of Surgery and Pathology, Children's Hospital and Harvard Medical School, Enders 1007, Boston, Massachusetts 02115;
  • Shuichi Takayama Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138,Surface Logix Inc., 50 Soldiers Field Place, Brighton, MA 02135.Department of Biomedical Engineering, University of Michigan, 2350 Hayward, 3304 GG Brown, Ann Arbor, Michigan 48109-2125.Departments of Surgery and Pathology, Children's Hospital and Harvard Medical School, Enders 1007, Boston, Massachusetts 02115;
  • Xingyu Jiang Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138,Surface Logix Inc., 50 Soldiers Field Place, Brighton, MA 02135.Department of Biomedical Engineering, University of Michigan, 2350 Hayward, 3304 GG Brown, Ann Arbor, Michigan 48109-2125.Departments of Surgery and Pathology, Children's Hospital and Harvard Medical School, Enders 1007, Boston, Massachusetts 02115;
  • Donald E. Ingber Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138,Surface Logix Inc., 50 Soldiers Field Place, Brighton, MA 02135.Department of Biomedical Engineering, University of Michigan, 2350 Hayward, 3304 GG Brown, Ann Arbor, Michigan 48109-2125.Departments of Surgery and Pathology, Children's Hospital and Harvard Medical School, Enders 1007, Boston, Massachusetts 02115;
Abstract
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Whitesides, George M., et al. “Soft Lithography in Biology and Biochemistry”. Annual Review of Biomedical Engineering, vol. 3, no. 1, 2001, pp. 335-73, https://doi.org/10.1146/annurev.bioeng.3.1.335.
Whitesides, G. M., Ostuni, E., Takayama, S., Jiang, X., & Ingber, D. E. (2001). Soft Lithography in Biology and Biochemistry. Annual Review of Biomedical Engineering, 3(1), 335-373. https://doi.org/10.1146/annurev.bioeng.3.1.335
Whitesides GM, Ostuni E, Takayama S, Jiang X, Ingber DE. Soft Lithography in Biology and Biochemistry. Annual Review of Biomedical Engineering. 2001;3(1):335-73.
Journal Categories
Medicine
Medicine (General)
Medical technology
Science
Biology (General)
Genetics
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Description

Discover the transformative power of soft lithography in biological and biochemical microfabrication. This review explores the principles and applications of soft lithography, a versatile set of techniques based on printing and molding with elastomeric stamps. It overcomes shortcomings of traditional photolithography, making it ideal for biological applications. Soft lithography enables precise control over surface molecular structures, pattern complex biological molecules, fabricate microfluidic channels, and manipulate cells. The simplicity and cost-effectiveness of producing prototype patterns and structures at biological feature sizes (≥50 μm) is highlighted. The use of self-assembled monolayers of alkanethiolates on gold allows exquisite control over surface biochemistry. This review provides a comprehensive overview of soft lithography's capabilities, highlighting its potential for creating innovative tools and platforms in biology and biochemistry. The techniques are particularly well-suited for biology research, where molecular structure and surface biochemistry can be tailored and controlled.

Published in the Annual Review of Biomedical Engineering, this article provides a broad overview of soft lithography and its applications in biology, aligning perfectly with the journal's scope. The review's focus on biomedical engineering techniques for biological applications directly fits with the journal's mission. Its exploration of microfabrication and surface biochemistry is relevant to the field of biomedical engineering.

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Citations Analysis
Category Category Repetition
Science: Chemistry851
Technology: Chemical technology627
Science: Chemistry: General. Including alchemy454
Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials422
Science: Physics413
The first research to cite this article was titled Single molecule research on surfaces: from analytics to construction and back and was published in 2001. The most recent citation comes from a 2024 study titled Single molecule research on surfaces: from analytics to construction and back . This article reached its peak citation in 2010 , with 125 citations.It has been cited in 543 different journals, 15% of which are open access. Among related journals, the Lab on a Chip cited this research the most, with 123 citations. The chart below illustrates the annual citation trends for this article.
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