How do cells use phosphorylated lipids for communication? This review delves into the synthesis and function of 3-phosphorylated inositol lipids, crucial second messengers that interact with the lipid-binding domains of various cellular proteins. These interactions influence the subcellular localization and aggregation of target proteins, and modulate their activity through allosteric effects. The generation of 3-phosphoinositides plays a vital role in diverse cellular pathways, thereby influencing essential cellular functions. This review emphasizes extracellular stimuli responsible for acutely triggering 3-phosphoinositide lipid synthesis, the enzymes involved in their synthesis and metabolism, and their diverse cell biological roles. Recent advances, driven by structural insights into lipid kinases, their interactions with inhibitors, and the interaction of their 3-phosphoinositide products with protein targets, are highlighted. The field is now moving towards genetic dissection of 3-phosphoinositide action in model organisms. This research has the potential to reveal the true organismal-level roles of 3-phosphoinositides in health and disease.
This review, published in the Annual Review of Biochemistry, aligns squarely with the journal’s focus on providing comprehensive overviews of key topics in biochemistry. By examining the synthesis, function, and regulation of 3-phosphorylated inositol lipids, the article contributes to the understanding of fundamental cellular signaling processes, a core area of biochemical research.
| Category | Category Repetition |
|---|---|
| Science: Biology (General) | 338 |
| Science: Chemistry: Organic chemistry: Biochemistry | 302 |
| Science: Biology (General): Cytology | 225 |
| Science: Biology (General): Genetics | 186 |
| Medicine: Medicine (General) | 185 |