Unlocking the secrets of programmed cell death! This comprehensive review delves into the intricate world of apoptosis signaling, highlighting its crucial role in multicellular organism development and disease prevention. By exploring the multiple independent pathways that trigger apoptosis and their convergence on a common machinery of cell destruction, this article provides a valuable overview of current knowledge in the field. This article provides scientists with a better understanding of cell regulatory machinery. The review summarizes how all apoptosis signaling pathways converge on a family of cysteine proteases that dismantle doomed cells. Dismantling and removal of doomed cells is accomplished by proteolysis of vital cellular constituents, DNA degradation, and phagocytosis by neighboring cells. Additionally, the article lists pressing questions and presents a novel model to explain biochemical and functional interactions between components of the cell death regulatory machinery. By illuminating the complex signaling cascades and regulatory mechanisms involved in apoptosis, this review serves as a valuable resource for researchers seeking to understand and manipulate cell death pathways for therapeutic purposes.
Published in the Annual Review of Biochemistry, this review aligns with the journal's focus on providing comprehensive overviews of key biochemical processes. The detailed exploration of apoptosis signaling and its molecular mechanisms fits directly within the journal's scope by examining critical cellular constituents, and serving researchers seeking to understand and manipulate cell death pathways for therapeutic purposes.
| Category | Category Repetition |
|---|---|
| Science: Biology (General) | 332 |
| Medicine: Medicine (General) | 255 |
| Science: Biology (General): Cytology | 230 |
| Science: Biology (General): Genetics | 222 |
| Science: Chemistry: Organic chemistry: Biochemistry | 190 |