Could shoulder pain signal a heart problem? This case report details a unique instance of neuralgic amyotrophy presenting as the primary symptom of infective endocarditis in a 35-year-old man. Initially experiencing severe right shoulder pain and muscle weakness after a dental filling, the patient's condition worsened despite standard treatments, developing additional symptoms like malaise and a petechial rash. After further developed signs, such as a heart murmur, investigations confirmed both infective endocarditis and neuralgic amyotrophy, highlighting a rare and previously undescribed association. This case emphasizes the importance of considering atypical presentations in medical diagnosis. Published in the *Postgraduate Medical Journal*, the report serves as a valuable reminder for clinicians to maintain a broad differential diagnosis, particularly when common symptoms are accompanied by unusual neurological manifestations. This study provides a valuable insight in internal medicine.
Published in the Postgraduate Medical Journal, this case report aligns with the journal's emphasis on disseminating practical clinical knowledge. By highlighting an unusual presentation of infective endocarditis, the report provides a valuable learning opportunity for general practitioners and other physicians. It underscores the importance of recognizing atypical symptoms to ensure accurate and timely diagnoses.