How can we predict the stiffness loss of bone after it's been damaged? This research develops a model to predict stiffness loss in bovine trabecular bone based on the presence of microdamage caused by compression. The modeling approach is applied at three levels: a single trabecula, a cellular solid, and a specimen with a localized damage band. How might such a model enable predictions of bone quality in humans? The model incorporates the presence of intact, damaged, and fractured trabeculae. The predictions of reduced modulus show good agreement with experimentally measured modulus reductions in post-yield compression. The study demonstrates that the predicted reduced modulus is relatively insensitive to changes in the input parameters. The findings provide a tool for understanding and predicting the mechanical behavior of damaged bone tissue. This has implications for developing better diagnostic techniques and treatments for osteoporosis and other bone-related conditions, and for optimizing interventions that enhance bone strength.
Published in the Journal of Biomechanical Engineering, this research aligns with the journal's focus on applying engineering principles to understand biological systems. By developing a model that predicts the mechanical behavior of bone tissue, the study falls within the scope of biomechanical engineering and its applications in understanding and treating musculoskeletal conditions.