Can drinking water contribute to the body burden of industrial solvents? This study investigates the potential influence of trichloroethylene (TRI) and tetrachloroethylene (PER) exposure through drinking water on the body burden in a group of 55 subjects with no known occupational solvent exposure from the city of Zagreb. It explores the quantitative relationships between TRI and PER concentrations in drinking water and the levels of their metabolite trichloroacetic acid (TCA) in plasma and urine. The research measured TRI and PER concentrations in blood and drinking water samples, as well as TCA levels in plasma and urine. Correlation analyses revealed significant relationships between TRI and PER in both blood and drinking water, as well as between TCA levels in urine and plasma. These quantitative relationships may indicate TCA as a possible biologic marker of environmental exposure to TRI and PER. These findings suggest that drinking water can be a significant source of exposure to TRI and PER, highlighting the importance of monitoring water quality to protect public health. The study underscores the potential of TCA as a biomarker for assessing environmental exposure to these solvents, aiding in future environmental monitoring and risk assessment efforts.