Unlocking the power of direct amination: This review highlights recent advances in transition-metal-catalyzed direct amination of aryl halides with ammonia, a process gaining traction for its broad substrate scope, functional group compatibility, and high selectivity. The study focuses on transition-metal-catalyzed syntheses of aniline derivatives from aryl halides. By reviewing various methods, including heat-driven and light-driven approaches, the article presents a comprehensive overview of the field. Palladium, copper, and nickel catalysts take center stage, demonstrating their respective roles in facilitating amination reactions. The review offers practical insights for chemists seeking efficient and selective methods for synthesizing aniline derivatives. This overview provides a valuable resource for researchers, emphasizing the potential of transition-metal catalysis in amination chemistry, and paving the way for future innovations in organic synthesis and material science.
Published in Synthesis, this review aligns perfectly with the journal's focus on synthetic organic chemistry. The direct amination of aryl halides is a fundamental transformation in organic synthesis, and this review highlights recent advances in this area, which is precisely what Synthesis aims to showcase to its readership.