How do cells ensure their components are in the right place? This review explores the principles governing organelle positioning in both motile and non-motile cells. It discusses how cells actively move, position, and anchor organelles to specific intracellular locations, highlighting the importance of this process for various cellular functions. The authors present a framework based on cytoskeletal forces and organelle-to-cytoskeleton connectivity to explain the active positioning of organelles. The review examines how different cells utilize varying mechanisms of force generation and organelle anchorage, and how the microenvironment influences organelle positioning. It particularly focuses on organelle positioning during cell migration, discussing novel findings on anchorage-independent mechanisms and their implications for both motile and stationary cells. This comprehensive overview provides valuable insights into the fundamental principles of cellular organization and function.
Published in EMBO reports, this review aligns with the journal's focus on cutting-edge research in molecular biology. By exploring the principles of organelle positioning, the article contributes to the journal's broader coverage of cellular mechanisms and their impact on biological processes. The review's emphasis on cytoskeletal dynamics and cellular architecture further complements the journal's focus on cell biology.
| Category | Category Repetition |
|---|---|
| Science: Biology (General): Cytology | 150 |
| Science: Biology (General): Genetics | 75 |
| Science: Biology (General) | 72 |
| Science: Science (General) | 18 |
| Science: Chemistry: Organic chemistry: Biochemistry | 17 |