How does a parent's age at conception influence their child's lifespan? This research reviews the existing knowledge on the effects of parental age on offspring, referencing Finch's extensive monograph. The focus is primarily on the impacts of advanced maternal age, specifically the increased risk of fetal aneuploidy and associated genetic disorders. The review discusses major maternal age-related changes in humans, such as the heightened occurrence of Down's syndrome, Kleinfelter's syndrome, Edward's syndrome, and Patau's syndrome. While acknowledging significant improvements in fetal death rates, it emphasizes that advanced maternal age remains a critical independent risk factor for fetal death. This synthesis underscores the importance of considering parental age, particularly advanced maternal age, in assessing offspring health risks. By highlighting the potential for genetic disorders and fetal death, the review provides valuable insights for reproductive health and family planning decisions.
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