Harnessing biofabrication for advanced immune system models: This review explores the current state of immune Organs-on-a-Chip (OoC) models, highlighting the crucial role of biofabrication technologies in bridging the gap between conceptual design and physiological relevance. Aiming to advance understanding of immune responses, the review emphasizes the need for precise biomimicry within microfluidic environments to create accurate and predictive human models. The review covers multifaceted aspects of immune cell behavior, crosstalk, and immune responses that are being replicated within microfluidic environments. It delves into the latest breakthroughs and challenges of biofabrication technologies in immune OoC platforms. This work guides researchers toward a deeper understanding of immune physiology and the development of more accurate and human predictive models for immune-related disorders, immune development, immune programming, and immune regulation. It is a valuable resource for those seeking to leverage OoC technology for advanced immunological research.
Published in Advanced Healthcare Materials, this review aligns with the journal's focus on cutting-edge technologies and materials for biomedical applications. The exploration of biofabrication in immune OoC models contributes to the journal's objective of showcasing innovative approaches for advancing healthcare and regenerative medicine.