| The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics | 2008/02/01 | English | 1,822 |
| Approaches to treat immune hot, altered and cold tumours with combination immunotherapies | 2019/01/04 | English | 1,817 |
| Drugs for bad bugs: confronting the challenges of antibacterial discovery | 2006/12/08 | English | 1,802 |
| Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer | 2004/05/01 | English | 1,719 |
| The influence of drug-like concepts on decision-making in medicinal chemistry | 2007/11/01 | English | 1,658 |
| The re-emergence of natural products for drug discovery in the genomics era | 2015/01/23 | English | 1,604 |
| The evolving role of natural products in drug discovery | 2005/02/24 | English | 1,575 |
| Protein kinases — the major drug targets of the twenty-first century? | 2002/04/01 | English | 1,573 |
| Angiogenesis: an organizing principle for drug discovery? | 2007/04/01 | English | 1,543 |
| Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery | 2005/12/01 | English | 1,526 |
| Aptamers as therapeutics | 2010/07/01 | English | 1,497 |
| Trends in GPCR drug discovery: new agents, targets and indications | 2017/10/27 | English | 1,490 |
| The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics | 2011/08/19 | English | 1,484 |
| Peroxynitrite: biochemistry, pathophysiology and development of therapeutics | 2007/08/01 | English | 1,482 |
| Delivery technologies for cancer immunotherapy | 2019/01/08 | English | 1,480 |
| Hydrogen sulphide and its therapeutic potential | 2007/11/01 | English | 1,442 |
| Protein therapeutics: a summary and pharmacological classification | 2008/01/01 | English | 1,414 |
| Cyclodextrin-based pharmaceutics: past, present and future | 2004/12/01 | English | 1,413 |
| Strategies and challenges for the next generation of antibody–drug conjugates | 2017/03/17 | English | 1,381 |
| Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities | 2008/12/01 | English | 1,380 |
| Metabonomics: a platform for studying drug toxicity and gene function | 2002/02/01 | English | 1,357 |
| Designing antimicrobial peptides: form follows function | 2011/12/16 | English | 1,344 |
| mRNA-based therapeutics — developing a new class of drugs | 2014/09/19 | English | 1,316 |
| Targeting G-quadruplexes in gene promoters: a novel anticancer strategy? | 2011/04/01 | English | 1,309 |
| The FGF family: biology, pathophysiology and therapy | 2009/03/01 | English | 1,290 |
| A comprehensive map of molecular drug targets | 2016/12/02 | English | 1,289 |
| Drugging the undruggable RAS: Mission Possible? | 2014/10/17 | English | 1,285 |
| Microtubule-binding agents: a dynamic field of cancer therapeutics | 2010/10/01 | English | 1,274 |
| Discovery and development of sorafenib: a multikinase inhibitor for treating cancer | 2006/10/01 | English | 1,254 |
| Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs | 2007/03/01 | English | 1,252 |