Gene Therapy

Title Publication Date Language Citations
Plat-E: an efficient and stable system for transient packaging of retroviruses2000/06/01English1,340
Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA1999/07/01English1,249
Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield1999/06/01English950
PEGylated DNA/transferrin–PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery1999/04/01English874
Gene Therapy Progress and Prospects: Nonviral vectors2002/11/29English665
Conditionally replicating herpes simplex virus mutant, G207 for the treatment of malignant glioma: results of a phase I trial2000/05/01English662
Magnetofection: enhancing and targeting gene delivery by magnetic force in vitro and in vivo2002/01/01English613
The influence of polymer structure on the interactions of cationic polymers with DNA and morphology of the resulting complexes1997/08/01English570
ICP34.5 deleted herpes simplex virus with enhanced oncolytic, immune stimulating, and anti-tumour properties2003/02/01English534
Immune responses to adenovirus and adeno-associated virus in humans1999/09/01English499
RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo2004/12/23English495
Self-complementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesis2001/08/01English472
Immune responses to gene therapy vectors: influence on vector function and effector mechanisms2004/09/29English451
The size of DNA/transferrin-PEI complexes is an important factor for gene expression in cultured cells1998/10/01English444
Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery2004/07/22English443
Antitumor effect of genetically engineered mesenchymal stem cells in a rat glioma model2004/05/13English414
Progress and prospects: immune responses to viral vectors2009/11/12English412
Metabolic instability of plasmid DNA in the cytosol: a potential barrier to gene transfer1999/04/01English411
Nonviral gene therapy: promises and challenges2000/01/01English410
Gene therapy progress and prospects: magnetic nanoparticle-based gene delivery2006/02/01English391
Inflammation and tumor microenvironments: defining the migratory itinerary of mesenchymal stem cells2008/04/10English388
On the mechanism whereby cationic lipids promote intracellular delivery of polynucleic acids2001/08/01English383
Toxicity evaluation of replication-competent herpes simplex virus (ICP 34.5 null mutant 1716) in patients with recurrent malignant glioma2000/05/01English383
Chitosan as a nonviral gene delivery system. Structure–property relationships and characteristics compared with polyethylenimine in vitro and after lung administration in vivo2001/07/01English366
Cell cycle dependence of gene transfer by lipoplex, polyplex and recombinant adenovirus2000/02/24English365
Adeno-associated virus vectors can be efficiently produced without helper virus1998/07/01English363
Adeno-associated virus terminal repeat (TR) mutant generates self-complementary vectors to overcome the rate-limiting step to transduction in vivo2003/11/17English362
Protamine sulfate enhances lipid-mediated gene transfer1997/09/01English328
In vivo gene transfer via intravenous administration of cationic lipid–protamine–DNA (LPD) complexes1997/09/01English319
Molecular basis of the inflammatory response to adenovirus vectors2003/05/20English313