Xenobiotica

Title Publication Date Language Citations
P450 in the rat and man: methods of investigation, substrate specificities and relevance to cancer1994/01/01English108
Hippuric acid as a major excretion product associated with black tea consumption2000/01/01English107
Differential effects of dietary flavonoids on drug metabolizing and antioxidant enzymes in female rat1999/01/01English105
Are free radicals involved in lead poisoning?1991/01/01English104
Reduction of Azo Food Dyes in Cultures ofProteus vulgaris1975/01/01English104
N-glucuronidation of drugs and other xenobiotics by human and animal UDP-glucuronosyltransferases2011/03/24English104
Fully automated analysis of activities catalysed by the major human liver cytochrome P450 (CYP) enzymes: assessment of human CYP inhibition potential1999/01/01English104
Plasma concentrations of individual tea catechins after a single oral dose in humans2001/01/01English104
The Fate of [14C]Phenol in Various Species1972/01/01English103
Antioxidant and free radical scavenging activity of isoflavone metabolites2003/09/01English103
Assessment of specificity of eight chemical inhibitors using cDNA-expressed cytochromes P4502000/01/01English102
Studies on the Different Metabolic Pathways of Antipyrine in Rats: Influence of Phenobarbital and 3-Methylcholanthrene Treatment1979/01/01English101
Metabolic disposition of gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, in rat, dog and man2004/10/01English101
Cytochrome P450-dependent metabolism of gefitinib2005/01/01English100
Evolution of the cytochrome P450 genes1989/01/01English100
The pharmacokinetics of propofol in laboratory animals1992/01/01English99
The Enzymic Formation of a Methylenedioxyphenyl Derivative Exhibiting an Isocyanide-like Spectrum with Reduced Cytochrome P-450 in Hepatic Microsomes1971/01/01English98
The metabolism of14C-labelled trimethylamine and itsN-oxide in man1987/01/01English98
Tissue disposition, excretion and metabolism of 2,2′,4,4′,5-pentabromodiphenyl ether (BDE-99) in the male Sprague-Dawley rat2002/01/01English98
Effects of bioflavonoids on hepatic P450 activities1995/01/01English98
Validation and application of Caco-2 assays for thein vitroevaluation of development candidate drugs as substrates or inhibitors of P-glycoprotein to support regulatory submissions2008/08/01English97
Pharmacokinetics, disposition and biotransformation of [14C]-radiolabelled valsartan in healthy male volunteers after a single oral dose1997/01/01English95
Algorithms for network analysis in systems-ADME/Tox using the MetaCore and MetaDrug platforms2006/01/01English93
Baicalin, an emerging multi-therapeutic agent: pharmacodynamics, pharmacokinetics, and considerations from drug development perspectives2010/03/15English93
Extensive metabolism of the flavonoid chrysin by human Caco-2 and Hep G2 cells1999/01/01English91
Biotransformation of Diclofenac Sodium (Voltaren®) in Animals and in Man.: II. Quantitative determination of the unchanged drug and principal phenolic metabolites, in urine and bile1979/01/01English91
Mechanisms of Azo Reduction byStreptococcus faecalisII. The Role of Soluble Flavins1971/01/01English91
Tissue distribution of drug-metabolizing enzymes in humans1988/01/01English91
Accumulation and metabolism of drugs and CYP probe substrates in zebrafish larvae2010/06/09English91
Effects of canthaxanthin, astaxanthin, lycopene and lutein on liver xenobiotic-metabolizing enzymes in the rat1996/01/01English90