Xenobiotica

Title Publication Date Language Citations
Elucidation of clearance mechanism of TP0463518, a novel hypoxia-inducible factor prolyl hydroxylase inhibitor: does a species difference in excretion routes exist between humans and animals?2022/07/03English
Pharmacokinetics of levonorgestrel and etonogestrel in rat or minipig following intravenous, subcutaneous, or intradermal administration2022/06/03English
Subcutaneous catabolism of peptide therapeutics: bioanalytical approaches and ADME considerations2022/08/03English
Comprehensive metabolism study of swertiamarin in rats using ultra high-performance liquid chromatography coupled with Quadrupole-Exactive Orbitrap mass spectrometry2021/01/07English
Effect and underlying mechanism of morin on the pharmacokinetics of diclofenac sodium in rats2021/09/19English
Prospective prediction of plasma pharmacokinetics of a novel immune-modulating agent in cancer patients after intra-tumoral administration: translation from non-clinical species to humans2021/10/28English
Commentary concerning the publication by Zheng X et al.: Metabolic activation of deferiprone mediated by CYP2A6 (Xenobiotica, published online 18 May 2021)2021/10/06English
Utility of preclinical species for uncertainty assessment and correction of prediction of human volume of distribution using the Rodgers-Lukacova model2022/07/03English
Species differences in liver microsomal hydrolysis of acyl glucuronide in humans and rats2022/07/03English
Cadmium-induced preeclampsia-like phenotype in the rat is related to decreased progesterone synthesis in the placenta2022/06/03English
Use of selective substrates and inhibitors to rapidly characterise batches of cryopreserved primary human hepatocytes for assessment of active uptake liability in drug discovery and development2022/08/03English
Drug peptide conjugates in human urine?2013/06/18English
Evaluation ofin vitrometabolic systems for common drugs of abuse. 1. Cocaine2013/05/15English
Urinary excretion profiles ofN-hydroxy-3,4-methylenedioxymethamphetamine in rats2011/03/22English
Curiosities in drug metabolism2014/04/29English
The usefulness of Øie–Tozer’s model in deriving pharmacokinetic changes in response to changes in the concentration of drug-binding plasma protein2015/11/02English
David Francis Victor Lewis (1949–2012)2012/07/09English
Acknowledgements2011/11/05English
Erratum1993/01/01English
Book Review1985/01/01English
Book Reviews1983/01/01English
Editorial1992/01/01English
Book Reviews1982/01/01English
R. E. McMahon1980/01/01English
Professor Dennis Parke andXenobiotica—An Appreciation1993/01/01English
Forthcoming Event1977/01/01English
Book Reviews1973/01/01English
Species variations in the N-methylation and quaternization of [14C]pyridine1982/01/01English
XIVth International Symposium on Medicinal Chemistry1996/01/01English
Book Reviews1974/01/01English