Human Gene Therapy

Titel Veröffentlichungsdatum Sprache Zitate
Delivery and Specificity of CRISPR/Cas9 Genome Editing Technologies for Human Gene Therapy2015/07/01English136
Herpes Simplex Virus Type 1 DNA Amplified as Bacterial Artificial Chromosome inEscherichia coli:Rescue of Replication-Competent Virus Progeny and Packaging of Amplicon Vectors1998/12/10English136
Catheter-Mediated Vascular Endothelial Growth Factor Gene Transfer to Human Coronary Arteries after Angioplasty2000/01/20English136
Moving Forward After Two Deaths in a Gene Therapy Trial of Myotubular Myopathy2020/07/01English136
“Sero-Switch” Adenovirus-MediatedIn VivoGene Transfer: Circumvention of Anti-Adenovirus Humoral Immune Defenses Against Repeat Adenovirus Vector Administration by Changing the Adenovirus Serotype1996/01/01English135
Circumvention of Anti-Adenovirus Neutralizing Immunity by Administration of an Adenoviral Vector of an Alternate Serotype1997/01/01English135
Analytical Anion-Exchange HPLC of Recombinant Type-5 Adenoviral Particles1997/03/01English134
Lipid-Mediated Enhancement of Transfection by a Nonviral Integrin-Targeting Vector1998/03/01English134
Safety Issues Related to Retroviral-Mediated Gene Transfer in Humans1991/04/01English134
Adeno-Associated Virus-Mediated Gene Transfer to the Brain: Duration and Modulation of Expression1999/01/20English132
Contribution of Plasmid DNA to Inflammation in the Lung after Administration of Cationic Lipid:pDNA Complexes1999/01/20English132
Therapeutic Potential of Multipotent Mesenchymal Stromal Cells and Their Extracellular Vesicles2015/08/01English132
VEGF Gene Transfer Reduces Intimal Thickening via Increased Production of Nitric Oxide in Carotid Arteries1997/10/10English131
In Vivo Delivery to Tumors of DNA Complexed with Linear Polyethylenimine1999/07/01English131
Adenovirus-Mediated Gene Transfer of the Human TIMP-1 Gene Inhibits Smooth Muscle Cell Migration and Neointimal Formation in Human Saphenous Vein1998/04/10English130
High-Titer Adeno-Associated Viral Vectors from a Rep/Cap Cell Line and Hybrid Shuttle Virus1998/11/01English130
Immune Responses to Reporter Proteins and High Viral Dose Limit Duration of Expression with Adenoviral Vectors: Comparison of E2a Wild Type and E2a Deleted Vectors1997/07/01English129
Purification of a Type 5 Recombinant Adenovirus Encoding Human p53 by Column Chromatography1995/11/01English129
4-1BB and CD28 Signaling Plays a Synergistic Role in Redirecting Umbilical Cord Blood T Cells Against B-Cell Malignancies2010/01/01English129
CMV-β-Actin Promoter Directs Higher Expression from an Adeno-Associated Viral Vector in the Liver than the Cytomegalovirus or Elongation Factor 1α Promoter and Results in Therapeutic Levels of Human Factor X in Mice2001/03/20English129
Improved Production and Purification of Minicircle DNA Vector Free of Plasmid Bacterial Sequences and Capable of Persistent Transgene ExpressionIn Vivo2005/01/01English129
Immune Response to Fetal Calf Serum by Two Adenosine Deaminase-Deficient Patients After T Cell Gene Therapy2002/09/01English129
Neuroprotective Gene Therapy for Huntington's Disease, Using Polymer-Encapsulated Cells Engineered to Secrete Human Ciliary Neurotrophic Factor: Results of a Phase I Study2004/10/01English128
Gene Transfer In Vivo with DNA–Liposome Complexes: Lack of Autoimmunity and Gonadal Localization1992/12/01English128
Direct Intratumoral Injection of an Adenovirus Expressing Interleukin-12 Induces Regression and Long-Lasting Immunity That Is Associated with Highly Localized Expression of Interleukin-121996/10/20English127
Emergence of Early Region 1-Containing Replication-Competent Adenovirus in Stocks of Replication-Defective Adenovirus Recombinants (ΔE1 + ΔE3) During Multiple Passages in 293 Cells1994/12/01English127
Adenovirus Vector-Based Vaccines for Human Immunodeficiency Virus Type 12005/02/01English126
Prolonged Transgene Expression in Cotton Rat Lung with Recombinant Adenoviruses Defective in E2a1994/10/01English126
Expression of Naked Plasmid DNA Injected into the Afferent and Efferent Vessels of Rodent and Dog Livers1997/10/10English126
Progress in Transcriptionally Targeted and Regulatable Vectors for Genetic Therapy1997/05/01English126