| Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin | 2010/01/19 | English | 290 |
| Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2 | 2012/10/19 | English | 281 |
| Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers | 2018/01/19 | English | 266 |
| Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist | 2010/03/16 | English | 242 |
| Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development | 2013/04/04 | English | 242 |
| Biocatalysis in the Pharmaceutical Industry: The Need for Speed | 2017/04/21 | English | 242 |
| Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity | 2014/09/08 | English | 213 |
| INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology | 2017/03/06 | English | 207 |
| Practical High-Throughput Experimentation for Chemists | 2017/05/26 | English | 206 |
| Discovery of TAK-875: A Potent, Selective, and Orally Bioavailable GPR40 Agonist | 2010/06/18 | English | 200 |
| Drawing the PDB: Protein−Ligand Complexes in Two Dimensions | 2010/08/31 | English | 197 |
| SMARTCyp: A 2D Method for Prediction of Cytochrome P450-Mediated Drug Metabolism | 2010/03/15 | English | 195 |
| Structures of Human Acetylcholinesterase Bound to Dihydrotanshinone I and Territrem B Show Peripheral Site Flexibility | 2013/09/30 | English | 192 |
| Identification of NVP-BKM120 as a Potent, Selective, Orally Bioavailable Class I PI3 Kinase Inhibitor for Treating Cancer | 2011/08/26 | English | 182 |
| Marine Natural Products in Medicinal Chemistry | 2018/09/13 | English | 178 |
| Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway | 2010/09/07 | English | 176 |
| Distinct Binding Mode of Multikinase Inhibitor Lenvatinib Revealed by Biochemical Characterization | 2014/11/20 | English | 176 |
| PROTAC Technology: Opportunities and Challenges | 2020/03/12 | English | 165 |
| Investigation of a Bicyclo[1.1.1]pentane as a Phenyl Replacement within an LpPLA2 Inhibitor | 2016/11/28 | English | 159 |
| Advent of Imidazo[1,2-a]pyridine-3-carboxamides with Potent Multi- and Extended Drug Resistant Antituberculosis Activity | 2011/03/29 | English | 153 |
| Discovery of Dabrafenib: A Selective Inhibitor of Raf Kinases with Antitumor Activity against B-Raf-Driven Tumors | 2013/02/18 | English | 153 |
| Discovery of GSK2656157: An Optimized PERK Inhibitor Selected for Preclinical Development | 2013/08/23 | English | 153 |
| Identification of 14 Known Drugs as Inhibitors of the Main Protease of SARS-CoV-2 | 2020/10/25 | English | 150 |
| Selective Inhibitors of Fibroblast Activation Protein (FAP) with a (4-Quinolinoyl)-glycyl-2-cyanopyrrolidine Scaffold | 2013/03/25 | English | 148 |
| Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2-HG in Vivo | 2012/09/17 | English | 144 |
| Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor | 2010/11/15 | English | 137 |
| Selective Dual Inhibitors of the Cancer-Related Deubiquitylating Proteases USP7 and USP47 | 2012/09/11 | English | 135 |
| Arylthioamides as H2S Donors: l-Cysteine-Activated Releasing Properties and Vascular Effects in Vitro and in Vivo | 2013/08/12 | English | 135 |
| Cobicistat (GS-9350): A Potent and Selective Inhibitor of Human CYP3A as a Novel Pharmacoenhancer | 2010/05/17 | English | 134 |
| Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor | 2012/03/02 | English | 133 |