Journal of Medicinal Chemistry

Titel Veröffentlichungsdatum Sprache Zitate
Role of Molecular Dynamics and Related Methods in Drug Discovery2016/02/08English652
Structure Based Drug Design of Crizotinib (PF-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal–Epithelial Transition Factor (c-MET) Kinase and Anaplastic Lymphoma Kinase (ALK)2011/08/18English650
Substituent Effects on the Antibacterial Activity of Nitrogen−Carbon-Linked (Azolylphenyl)oxazolidinones with Expanded Activity Against the Fastidious Gram-Negative Organisms Haemophilus influenzae and Moraxella catarrhalis2000/02/17English641
Macrocycles Are Great Cycles: Applications, Opportunities, and Challenges of Synthetic Macrocycles in Drug Discovery2011/03/07English639
N-Methylated Cyclic RGD Peptides as Highly Active and Selective αVβ3Integrin Antagonists1999/07/24English633
(2R)-4-Oxo-4-[3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin- 7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine:  A Potent, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes2004/12/13English633
Generation of a Set of Simple, Interpretable ADMET Rules of Thumb2008/01/31English624
Pyrazole Ligands:  Structure−Affinity/Activity Relationships and Estrogen Receptor-α-Selective Agonists2000/11/28English610
The “Cyclopropyl Fragment” is a Versatile Player that Frequently Appears in Preclinical/Clinical Drug Molecules2016/06/30English608
Toward Improved Anti-HIV Chemotherapy: Therapeutic Strategies for Intervention with HIV Infections1995/07/01English590
The Identification of 2-(1H-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a Potent, Selective, Orally Bioavailable Inhibitor of Class I PI3 Kinase for the Treatment of Cancer2008/08/29English587
Comparative Evaluation of 11 Scoring Functions for Molecular Docking2003/05/08English587
The PDBbind Database:  Collection of Binding Affinities for Protein−Ligand Complexes with Known Three-Dimensional Structures2004/05/04English580
Inhibition of Human Telomerase by a G-Quadruplex-Interactive Compound1997/07/01English579
Complexes of .NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects1991/11/01English563
6α-Ethyl-Chenodeoxycholic Acid (6-ECDCA), a Potent and Selective FXR Agonist Endowed with Anticholestatic Activity2002/07/20English561
A Survey of the Role of Noncovalent Sulfur Interactions in Drug Design2015/03/03English559
Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide2015/09/11English556
Structure-Based Design of Spiro-oxindoles as Potent, Specific Small-Molecule Inhibitors of the MDM2−p53 Interaction2006/05/13English550
Hydrocarbon-Stapled Peptides: Principles, Practice, and Progress2014/03/06English548
Assessing Atropisomer Axial Chirality in Drug Discovery and Development2011/09/15English546
Medicinal Chemistry of Combretastatin A4:  Present and Future Directions2006/04/27English540
Structure−Activity Relationships of Polymyxin Antibiotics2009/10/29English536
Estrogen Receptor-β Potency-Selective Ligands:  Structure−Activity Relationship Studies of Diarylpropionitriles and Their Acetylene and Polar Analogues2001/10/16English531
Using Deuterium in Drug Discovery: Leaving the Label in the Drug2013/12/02English528
A Bioavailability Score2005/04/05English526
Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability1980/06/01English523
Remarkable Potential of the α-Aminophosphonate/Phosphinate Structural Motif in Medicinal Chemistry2011/08/05English521
An Overview of Severe Acute Respiratory Syndrome–Coronavirus (SARS-CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy2016/02/15English517
Synthesis and structure-activity relationships of antibacterial phosphonopeptides incorporating (1-aminoethyl)phosphonic acid and (aminomethyl)phosphonic acid1986/01/01English512