Journal of Medicinal Chemistry

Titel Veröffentlichungsdatum Sprache Zitate
Structure−Activity Relationships for Cytotoxic Ruthenium(II) Arene Complexes Containing N,N-, N,O-, and O,O-Chelating Ligands2006/10/14English407
Discovery of RG7388, a Potent and Selective p53–MDM2 Inhibitor in Clinical Development2013/07/16English402
De Novo Antimicrobial Peptides with Low Mammalian Cell Toxicity1996/01/01English401
Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor2014/10/01English400
New developments in calcium ion channel antagonists1983/06/01English400
Discovery of 5-[5-Fluoro-2-oxo-1,2- dihydroindol-(3Z)-ylidenemethyl]-2,4- dimethyl-1H-pyrrole-3-carboxylic Acid (2-Diethylaminoethyl)amide, a Novel Tyrosine Kinase Inhibitor Targeting Vascular Endothelial and Platelet-Derived Growth Factor Receptor Tyrosine Kinase2003/03/01English400
Structure−Function Studies on the New Growth Hormone-Releasing Peptide, Ghrelin:  Minimal Sequence of Ghrelin Necessary for Activation of Growth Hormone Secretagogue Receptor 1a2000/10/26English400
Ureido-Substituted Benzenesulfonamides Potently Inhibit Carbonic Anhydrase IX and Show Antimetastatic Activity in a Model of Breast Cancer Metastasis2011/03/01English399
Discovery of Indoles as Potent and Selective Inhibitors of the Deacetylase SIRT12005/11/09English399
HIV inhibitory natural products. Part 7. The calanolides, a novel HIV-inhibitory class of coumarin derivatives from the tropical rainforest tree, Calophyllum lanigerum1992/07/01English399
A Shape-Based 3-D Scaffold Hopping Method and Its Application to a Bacterial Protein−Protein Interaction2005/02/10English397
Emerging and Re-Emerging Warheads for Targeted Covalent Inhibitors: Applications in Medicinal Chemistry and Chemical Biology2018/12/19English388
Structures of Three Classes of Anticancer Agents Bound to the Human Topoisomerase I−DNA Covalent Complex2005/02/24English388
Discovery of (10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a Macrocyclic Inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-ros Oncogene 1 (ROS1) with Preclinical Brain Exposure and Broad-Spectrum Potency against ALK-Resistant Mutations2014/06/03English388
Specific Plant Terpenoids and Lignoids Possess Potent Antiviral Activities against Severe Acute Respiratory Syndrome Coronavirus2007/07/31English386
2003 Claude S. Hudson Award Address in Carbohydrate Chemistry. Heparin:  Structure and Activity2003/05/20English386
Synthesis and Biological Evaluations of 3-Substituted Indolin-2-ones:  A Novel Class of Tyrosine Kinase Inhibitors That Exhibit Selectivity toward Particular Receptor Tyrosine Kinases1998/06/09English384
5-(Diethoxyphosphoryl)-5-methyl-1-pyrroline N-oxide: A New Efficient Phosphorylated Nitrone for the in Vitro and in Vivo Spin Trapping of Oxygen-Centered Radicals1995/01/01English381
Relationships between the structure of taxol analogs and their antimitotic activity1991/03/01English380
Property-Based Design:  Optimization of Drug Absorption and Pharmacokinetics2001/03/29English379
Molecular Recognition of Protein Kinase Binding Pockets for Design of Potent and Selective Kinase Inhibitors2007/01/10English379
Unusual Amino Acids in Medicinal Chemistry2016/09/30English378
Through the “Gatekeeper Door”: Exploiting the Active Kinase Conformation2010/04/08English378
Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 Variants2004/04/06English378
Structural Interaction Fingerprint (SIFt):  A Novel Method for Analyzing Three-Dimensional Protein−Ligand Binding Interactions2003/12/12English376
Role of Reactive Oxygen Species (ROS) in Therapeutics and Drug Resistance in Cancer and Bacteria2017/02/14English374
Development of a new physicochemical model for brain penetration and its application to the design of centrally acting H2 receptor histamine antagonists1988/03/01English372
High-Throughput Permeability pH Profile and High-Throughput Alkane/Water logPwith Artificial Membranes2001/02/03English372
Three-Dimensional Quantitative Structure−Activity Relationship Analyses Using Comparative Molecular Field Analysis and Comparative Molecular Similarity Indices Analysis To Elucidate Selectivity Differences of Inhibitors Binding to Trypsin, Thrombin, and Factor Xa1999/01/27English370
Comparative in Vivo Stability of Copper-64-Labeled Cross-Bridged and Conventional Tetraazamacrocyclic Complexes2004/02/12English370