LRRK2 kinase inhibition reverses G2019S mutation-dependent effects on tau pathology progression

Article Properties
  • Language
    English
  • DOI (url)
    10.1186/s40035-024-00403-2
  • Publication Date
    2024/03/04
  • Journal
    Translational Neurodegeneration
  • Indian UGC (journal)
  • Refrences
    60
  • Noah Lubben
  • Julia K. Brynildsen
  • Connor M. Webb
  • Howard L. Li
  • Cheryl E. G. Leyns
  • Lakshmi Changolkar
  • Bin Zhang
  • Emily S. Meymand
  • Mia O’Reilly
  • Zach Madaj
  • Daniella DeWeerd
  • Matthew J. Fell
  • Virginia M. Y. Lee
  • Dani S. Bassett
  • Michael X. Henderson ORCID (unauthenticated)
Abstract
Cite
Lubben, Noah, et al. “LRRK2 Kinase Inhibition Reverses G2019S Mutation-Dependent Effects on Tau Pathology Progression”. Translational Neurodegeneration, vol. 13, no. 1, 2024, https://doi.org/10.1186/s40035-024-00403-2.
Lubben, N., Brynildsen, J. K., Webb, C. M., Li, H. L., Leyns, C. E. G., Changolkar, L., Zhang, B., Meymand, E. S., O’Reilly, M., Madaj, Z., DeWeerd, D., Fell, M. J., Lee, V. M. Y., Bassett, D. S., & Henderson, M. X. (2024). LRRK2 kinase inhibition reverses G2019S mutation-dependent effects on tau pathology progression. Translational Neurodegeneration, 13(1). https://doi.org/10.1186/s40035-024-00403-2
Lubben, Noah, Julia K. Brynildsen, Connor M. Webb, Howard L. Li, Cheryl E. G. Leyns, Lakshmi Changolkar, Bin Zhang, et al. “LRRK2 Kinase Inhibition Reverses G2019S Mutation-Dependent Effects on Tau Pathology Progression”. Translational Neurodegeneration 13, no. 1 (2024). https://doi.org/10.1186/s40035-024-00403-2.
Lubben N, Brynildsen JK, Webb CM, Li HL, Leyns CEG, Changolkar L, et al. LRRK2 kinase inhibition reverses G2019S mutation-dependent effects on tau pathology progression. Translational Neurodegeneration. 2024;13(1).
Journal Categories
Medicine
Internal medicine
Neurosciences
Biological psychiatry
Neuropsychiatry
Medicine
Internal medicine
Neurosciences
Biological psychiatry
Neuropsychiatry
Neurology
Diseases of the nervous system
Refrences
Title Journal Journal Categories Citations Publication Date
Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy Nature
  • Science: Science (General)
 109 2023
10.1056/NEJMoa2212948 New England Journal of Medicine
  • Medicine: Medicine (General)
  • Medicine: Internal medicine
  • Medicine: Medicine (General)
  • Medicine: Medicine (General)
 2023
LRRK2 suppresses lysosome degradative activity in macrophages and microglia through MiT-TFE transcription factor inhibition

 Proceedings of the National Academy of Sciences
  • Science: Science (General)
 9 2023
Discovery of MK-1468: A Potent, Kinome-Selective, Brain-Penetrant Amidoisoquinoline LRRK2 Inhibitor for the Potential Treatment of Parkinson’s Disease Journal of Medicinal Chemistry
  • Medicine: Therapeutics. Pharmacology
  • Science: Chemistry: Analytical chemistry
  • Science: Chemistry
 1 2023
Tau activation of microglial cGAS–IFN reduces MEF2C-mediated cognitive resilience

 Nature Neuroscience
  • Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
  • Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
  • Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
 36 2023
Refrences Analysis
Category Category Repetition
Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry43
Science: Biology (General)20
Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system12
Science: Chemistry: Organic chemistry: Biochemistry12
Medicine: Medicine (General)8
Science: Biology (General): Cytology6
Medicine: Public aspects of medicine: Toxicology. Poisons5
Medicine: Therapeutics. Pharmacology5
Science: Science (General)5
Science3
Medicine: Internal medicine: Special situations and conditions: Geriatrics2
Medicine: Pathology2
Science: Biology (General): Genetics2
Medicine2
Science: Chemistry: Analytical chemistry1
Science: Chemistry1
Science: Mathematics: Probabilities. Mathematical statistics1
Science: Mathematics1
Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy1
Medicine: Internal medicine1
The category Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry 43 is the most frequently represented among the references in this article. It primarily includes studies from Science Translational Medicine and Acta Neuropathologica Communications. The chart below illustrates the number of referenced publications per year.
Refrences used by this article by year