Pharmacogenetics and Genomics

Title Publication Date Language Citations
Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily2005/10/01English599
Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions2006/04/01English468
SLCO1B1 polymorphism markedly affects the pharmacokinetics of simvastatin acid2006/12/01English357
Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stability2005/10/01English355
Influence of CYP2B6 polymorphism on plasma and intracellular concentrations and toxicity of efavirenz and nevirapine in HIV-infected patients2005/01/01English293
Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B1*5, SLCO1B1*15 and SLCO1B1*15+C1007G, by using transient expression systems of HeLa and HEK293 cells2005/07/01English281
CYP2D6 worldwide genetic variation shows high frequency of altered activity variants and no continental structure2007/02/01English275
Different contributions of polymorphisms in VKORC1 and CYP2C9 to intra- and inter-population differences in maintenance dose of warfarin in Japanese, Caucasians and African-Americans2006/02/01English264
Mutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with drug-induced liver injury2007/01/01English205
Polymorphisms of the 5-HT2C receptor and leptin genes are associated with antipsychotic drug-induced weight gain in Caucasian subjects with a first-episode psychosis2005/04/01English193
Genetic variability of CYP2B6 in populations of African and Asian origin: allele frequencies, novel functional variants, and possible implications for anti-HIV therapy with efavirenz2005/12/01English190
The manganese superoxide dismutase Ala16Val dimorphism modulates both mitochondrial import and mRNA stability2005/05/01English181
Significance of a common single nucleotide polymorphism in exon 10 of the follicle-stimulating hormone (FSH) receptor gene for the ovarian response to FSH: a pharmacogenetic approach to controlled ovarian hyperstimulation2005/07/01English145
Generation of gene knockouts and mutant models in the laboratory rat by ENU-driven target-selected mutagenesis2006/03/01English126
??1-Adrenergic receptor polymorphisms and left ventricular remodeling changes in response to ??-blocker therapy2005/04/01English121
Characterization of the monomethylarsonate reductase and dehydroascorbate reductase activities of Omega class glutathione transferase variants: implications for arsenic metabolism and the age-at-onset of Alzheimer's and Parkinson's diseases2005/07/01English121
Association of Vitamin K epoxide reductase complex 1 (VKORC1) variants with warfarin dose in a Hong Kong Chinese patient population2005/10/01English119
PON1 status of farmworker mothers and children as a predictor of organophosphate sensitivity2006/03/01English114
Optimization of cytochrome P4502D6 (CYP2D6) phenotype assignment using a genotyping algorithm based on allele frequency data1999/12/01English114
Genotype–activity relationship for Mn-superoxide dismutase, glutathione peroxidase 1 and catalase in humans2006/04/01English114
The A1 allele of the human D2 dopamine receptor gene is associated with increased activity of striatal L-amino acid decarboxylase in healthy subjects2005/06/01English106
Identification of a novel specific CYP2B6 allele in Africans causing impaired metabolism of the HIV drug efavirenz2006/03/01English104
Effect of intestinal CYP3A5 on postoperative tacrolimus trough levels in living-donor liver transplant recipients2006/02/01English103
The μ-opioid receptor gene polymorphism 118A>G depletes alfentanil-induced analgesia and protects against respiratory depression in homozygous carriers2006/09/01English102
A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of colorectal cancer2005/08/01English101
Thiopurine S-methyltransferase pharmacogenetics: variant allele functional and comparative genomics2005/11/01English96
MRP2 haplotypes confer differential susceptibility to toxic liver injury2007/06/01English94
A mutation in the drug transporter gene ABCC2 associated with impaired methotrexate elimination2005/05/01English93
Association between beta-1 and beta-2 adrenergic receptor gene polymorphisms and the response to beta-blockade in patients with stable congestive heart failure2005/03/01English90
Relative impact of CYP3A genotype and concomitant medication on the severity of atorvastatin-induced muscle damage2005/06/01English87