Title	Publication Date	Language	Citations
Practical methods for incorporating summary time-to-event data into meta-analysis	2007/06/07	English	4,142
Developing core outcome sets for clinical trials: issues to consider	2012/08/06	English	1,137
The COMET Handbook: version 1.0	2017/06/01	English	1,055
CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials	2010/03/24	English	966
How to select outcome measurement instruments for outcomes included in a “Core Outcome Set” – a practical guideline	2016/09/13	English	618
Prevention of non-communicable disease in a population in nutrition transition: Tehran Lipid and Glucose Study phase II	2009/01/25	English	612
What influences recruitment to randomised controlled trials? A review of trials funded by two UK funding agencies	2006/04/07	English	605
A literature review on the representativeness of randomized controlled trial samples and implications for the external validity of trial results	2015/11/03	English	523
OMERACT: An international initiative to improve outcome measurement in rheumatology	2007/11/26	English	360
Theory of Change: a theory-driven approach to enhance the Medical Research Council's framework for complex interventions	2014/07/05	English	352
Sample size requirements to estimate key design parameters from external pilot randomised controlled trials: a simulation study	2014/07/03	English	350
Standardising outcomes for clinical trials and systematic reviews	2007/11/26	English	334
Assessing and reporting heterogeneity in treatment effects in clinical trials: a proposal	2010/08/12	English	323
Making trials matter: pragmatic and explanatory trials and the problem of applicability	2009/06/03	English	299
The risks and rewards of covariate adjustment in randomized trials: an assessment of 12 outcomes from 8 studies	2014/04/23	English	265
A reinvestigation of recruitment to randomised, controlled, multicenter trials: a review of trials funded by two UK funding agencies	2013/06/09	English	261
Reporting bias in medical research - a narrative review	2010/04/13	English	259
Through the looking glass: understanding non-inferiority	2011/05/03	English	258
Interventions to improve recruitment and retention in clinical trials: a survey and workshop to assess current practice and future priorities	2014/10/16	English	237
Core Outcome Measures in Effectiveness Trials (COMET) initiative: protocol for an international Delphi study to achieve consensus on how to select outcome measurement instruments for outcomes included in a ‘core outcome set’	2014/06/25	English	213
The challenges faced in the design, conduct and analysis of surgical randomised controlled trials	2009/02/06	English	209
Why clinical trial outcomes fail to translate into benefits for patients	2017/03/14	English	201
MR CLEAN, a multicenter randomized clinical trial of endovascular treatment for acute ischemic stroke in the Netherlands: study protocol for a randomized controlled trial	2014/09/01	English	200
Systematic review of basket trials, umbrella trials, and platform trials: a landscape analysis of master protocols	2019/09/18	English	195
Reasons for participating in randomised controlled trials: conditional altruism and considerations for self	2010/03/22	English	191
Design, analysis, and presentation of crossover trials	2009/04/30	English	189
The WOMAN Trial (World Maternal Antifibrinolytic Trial): tranexamic acid for the treatment of postpartum haemorrhage: an international randomised, double blind placebo controlled trial	2010/04/16	English	189
Criteria for Reporting the Development and Evaluation of Complex Interventions in healthcare: revised guideline (CReDECI 2)	2015/05/03	English	186
Treatment of Middle East Respiratory Syndrome with a combination of lopinavir-ritonavir and interferon-β1b (MIRACLE trial): study protocol for a randomized controlled trial	2018/01/30	English	180
Clear obstacles and hidden challenges: understanding recruiter perspectives in six pragmatic randomised controlled trials	2014/01/06	English	172