SLAS Discovery

Title Publication Date Language Citations
A Simplified Method for Quantifying Cell Migration/Wound Healing in 96-Well Plates2010/04/01English126
Universal Screening Methods and Applications of ThermoFluor®2006/10/01English126
DMSO-Related Effects in Protein Characterization2006/03/01English124
Median Absolute Deviation to Improve Hit Selection for Genome-Scale RNAi Screens2008/02/01English124
High-Throughput Screening of G Protein-Coupled Receptor Antagonists Using a Bioluminescence Resonance Energy Transfer 1-Based β-Arrestin2 Recruitment Assay2005/08/01English119
High-Content Screening: A New Approach to Easing Key Bottlenecks in the Drug Discovery Process1997/06/01English119
A Thallium-Sensitive, Fluorescence-Based Assay for Detecting and Characterizing Potassium Channel Modulators in Mammalian Cells2004/12/01English116
High-Throughput Screening: Update on Practices and Success2006/10/01English114
Multiparameter In Vitro Assessment of Compound Effects on Cardiomyocyte Physiology Using iPSC Cells2013/01/01English110
RNA-Dependent RNA Polymerase as a Target for COVID-19 Drug Discovery2020/12/01English104
Epigenetic Drug Discovery: Targeting DNA Methyltransferases2012/01/01English103
Advanced Development of Primary Pancreatic Organoid Tumor Models for High-Throughput Phenotypic Drug Screening2018/07/01English102
A High-Throughput Cell-Based Assay for Inhibitors of ABCG2 Activity2006/03/01English101
Comparison of Methods for Image-Based Profiling of Cellular Morphological Responses to Small-Molecule Treatment2013/12/01English100
Modulation of NF-κB Signaling as a Therapeutic Target in Autoimmunity2016/03/01English100
Three Mechanistically Distinct Kinase Assays Compared: Measurement of Intrinsic ATPase Activity Identified the Most Comprehensive Set of ITK Inhibitors2007/02/01English99
Application of a High-Content Multiparameter Cytotoxicity Assay to Prioritize Compounds Based on Toxicity Potential in Humans2008/07/01English99
A Fluorescent Ligand-Binding Alternative Using Tag-lite® Technology2010/12/01English98
Are GPCRs Still a Source of New Targets?2013/10/01English98
3D Cell-Based Assays for Drug Screens: Challenges in Imaging, Image Analysis, and High-Content Analysis2019/07/01English98
A Novel Membrane Potential-Sensitive Fluorescent Dye Improves Cell-Based Assays for Ion Channels2002/02/01English98
A New Approach to Drug Discovery: High-Throughput Screening of Microbial Natural Extracts against Aspergillus fumigatus Using Resazurin2012/04/01English96
Assay Establishment and Validation of a High-Throughput Screening Platform for Three-Dimensional Patient-Derived Colon Cancer Organoid Cultures2016/10/01English96
Mechanism-Based Inhibition: Deriving KI and kinact Directly from Time-Dependent IC50 Values2009/09/01English96
Evaluating Cellular Impedance Assays for Detection of GPCR Pleiotropic Signaling and Functional Selectivity2009/03/01English96
3D Models of Epithelial-Mesenchymal Transition in Breast Cancer Metastasis: High-Throughput Screening Assay Development, Validation, and Pilot Screen2011/02/01English95
Screening for Ligands Using a Generic and High-Throughput Light-Scattering-Based Assay2006/12/01English95
The Evolution of MALDI-TOF Mass Spectrometry toward Ultra-High-Throughput Screening: 1536-Well Format and Beyond2016/02/01English94
Prediction of Off-Target Effects on Angiotensin-Converting Enzyme 22011/09/01English94
SIRT1 Modulating Compounds from High-Throughput Screening as Anti-Inflammatory and Insulin-Sensitizing Agents2006/12/01English93