Journal of Medicinal Chemistry

Title Publication Date Language Citations
Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists1988/12/01English1,078
Data-Mining for Sulfur and Fluorine: An Evaluation of Pharmaceuticals To Reveal Opportunities for Drug Design and Discovery2013/10/29English1,062
Prediction of Drug Absorption Using Multivariate Statistics2000/09/19English1,059
Aromatic substituent constants for structure-activity correlations1973/11/01English954
Discovery of N-(2-Chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a Dual Src/Abl Kinase Inhibitor with Potent Antitumor Activity in Preclinical Assays2004/12/01English951
Principles and Applications of Halogen Bonding in Medicinal Chemistry and Chemical Biology2013/01/03English950
Surflex:  Fully Automatic Flexible Molecular Docking Using a Molecular Similarity-Based Search Engine2003/01/21English940
Benchmarking Sets for Molecular Docking2006/10/26English936
Designed Multiple Ligands. An Emerging Drug Discovery Paradigm2005/09/24English899
Structures of Human Acetylcholinesterase in Complex with Pharmacologically Important Ligands2012/11/12English892
Physicochemical High Throughput Screening:  Parallel Artificial Membrane Permeation Assay in the Description of Passive Absorption Processes1998/03/01English877
Current Clinical and Preclinical Photosensitizers for Use in Photodynamic Therapy2004/06/19English867
Applications of Combinatorial Technologies to Drug Discovery. 1. Background and Peptide Combinatorial Libraries1994/04/01English852
Multi-target-Directed Ligands To Combat Neurodegenerative Diseases2008/01/09English831
Applications of Combinatorial Technologies to Drug Discovery. 2. Combinatorial Organic Synthesis, Library Screening Strategies, and Future Directions1994/05/01English828
A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening2002/03/09English777
Organosilicon Molecules with Medicinal Applications2012/11/06English755
Synthesis and Evaluation of 11C-Labeled 6-Substituted 2-Arylbenzothiazoles as Amyloid Imaging Agents2003/05/24English741
Structural Basis for Inhibition of the Hsp90 Molecular Chaperone by the Antitumor Antibiotics Radicicol and Geldanamycin1999/01/01English724
The Current State of Peptide Drug Discovery: Back to the Future?2017/08/11English701
In Vitro and in Vivo Evaluation of Ruthenium(II)−Arene PTA Complexes2005/05/21English686
Polypharmacology: Challenges and Opportunities in Drug Discovery2014/06/25English685
Protease Inhibitors:  Current Status and Future Prospects2000/02/01English682
1,2,3-Triazole-[2,5-Bis-O-(tert-butyldimethylsilyl)-.beta.-D-ribofuranosyl]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole 2'',2''-dioxide) (TSAO) Analogs: Synthesis and Anti-HIV-1 Activity1994/11/01English682
Simple Selection Criteria for Drug-like Chemical Matter2001/05/15English677
Dihydropyrimidine calcium channel blockers. 3. 3-Carbamoyl-4-aryl-1,2,3,4-tetrahydro-6-methyl-5-pyrimidinecarboxylic acid esters as orally effective antihypertensive agents1991/02/01English672
Inhibition of Cancer Cell Growth by Ruthenium(II) Arene Complexes2001/10/01English668
A General and Fast Scoring Function for Protein−Ligand Interactions:  A Simplified Potential Approach1999/02/24English661
Comparison of Shape-Matching and Docking as Virtual Screening Tools2006/12/13English657
Varenicline:  An α4β2 Nicotinic Receptor Partial Agonist for Smoking Cessation2005/04/23English652